Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/80288
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Chan, LH | - |
dc.creator | Zhou, L | - |
dc.creator | Ng, KY | - |
dc.creator | Wong, TL | - |
dc.creator | Lee, TK | - |
dc.creator | Sharma, R | - |
dc.creator | Loong, JH | - |
dc.creator | Ching, YP | - |
dc.creator | Yuan, YF | - |
dc.creator | Xie, D | - |
dc.creator | Lo, CM | - |
dc.creator | Man, K | - |
dc.creator | Artegiani, B | - |
dc.creator | Clevers, H | - |
dc.creator | Yan, HH | - |
dc.creator | Leung, SY | - |
dc.creator | Richard, S | - |
dc.creator | Guan, XY | - |
dc.creator | Huen, MSY | - |
dc.creator | Ma, S | - |
dc.date.accessioned | 2019-01-30T09:14:40Z | - |
dc.date.available | 2019-01-30T09:14:40Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/80288 | - |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | © 2018 The Author(s). | en_US |
dc.rights | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Chan, L.H., Zhou, L., Ng, K.Y., Wong, T.L., Lee, T.K., Sharma, R., ... & Ma, S. (2018). PRMT6 regulates RAS/RAF binding and MEK/ERK-Mediated cancer sternness activities in hepatocellular carcinoma through CRAF methylation. Cell reports, 25 (3), 690-701 is available at https://dx.doi.org/10.1016/j.celrep.2018.09.053 | en_US |
dc.title | PRMT6 regulates RAS/RAF binding and MEK/ERK-Mediated cancer sternness activities in hepatocellular carcinoma through CRAF methylation | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 690 | - |
dc.identifier.epage | 701 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 3 | - |
dc.identifier.doi | 10.1016/j.celrep.2018.09.053 | - |
dcterms.abstract | Arginine methylation is a post-translational modification that plays pivotal roles in signal transduction and gene transcription during cell fate determination. We found protein methyltransferase 6 (PRMT6) to be frequently downregulated in hepatocellular carcinoma (HCC) and its expression to negatively correlate with aggressive cancer features in HCC patients. Silencing of PRMT6 promoted the tumor-initiating, metastasis, and therapy resistance potential of HCC cell lines and patient-derived organoids. Consistently, loss of PRMT6 expression aggravated liver tumorigenesis in a chemical-induced HCC PRMT6 knockout (PRMT6(-/-)) mouse model. Integrated transcriptome and protein-protein interaction studies revealed an enrichment of genes implicated in RAS signaling and showed that PRMT6 interacted with CRAF on arginine 100, which decreased its RAS binding potential and altered its downstream MEK/ERK signaling. Our work describes a critical repressive function for PRMT6 in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Cell reports, Oct. 2018, v. 25, no. 3, p. 690-701 | - |
dcterms.isPartOf | Cell reports | - |
dcterms.issued | 2018 | - |
dc.identifier.isi | WOS:000448217500014 | - |
dc.identifier.scopus | 2-s2.0-85054755052 | - |
dc.identifier.pmid | 30332648 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.description.validate | 201901 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Chan_RAS_RAF_MEK.pdf | 7.52 MB | Adobe PDF | View/Open |
Page views
124
Last Week
1
1
Last month
Citations as of Aug 4, 2024
Downloads
62
Citations as of Aug 4, 2024
SCOPUSTM
Citations
78
Citations as of Aug 8, 2024
WEB OF SCIENCETM
Citations
77
Last Week
0
0
Last month
Citations as of Aug 8, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.