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Title: Ocular higher-order aberrations and axial eye growth in young Hong Kong children
Authors: Lau, JK 
Vincent, SJ
Collins, MJ
Cheung, SW 
Cho, P 
Issue Date: 2018
Source: Scientific reports, 2018, v. 8, 6726
Abstract: This retrospective longitudinal analysis aimed to investigate the association between ocular higherorder aberrations (HOAs) and axial eye growth in Hong Kong children. Measures of axial length and ocular HOAs under cycloplegia were obtained annually over a two-year period from 137 subjects aged 8.8 ± 1.4 years with mean spherical equivalent refraction of-2.04 ± 2.38 D. A significant negative association was observed between the RMS of total HOAs and axial eye growth (P = 0.03), after adjusting for other significant predictors of axial length including age, sex and refractive error. Similar negative associations with axial elongation were found for the RMS of spherical aberrations (Z4 0 and Z6 0 combined) (P = 0.037). Another linear mixed model also showed that greater levels of vertical trefoil (Z3 )-3 , primary spherical aberration (Z )4 0 and negative oblique trefoil (·) Z3 3 were associated with slower axial elongation and longer axial length (all P < 0.05). These findings support the potential role of HOAs, image quality and a vision-dependent mechanism in childhood eye growth.
Publisher: Nature Publishing Group
Journal: Scientific reports 
EISSN: 2045-2322
DOI: 10.1038/s41598-018-24906-x
Rights: © The Author(s) 2018
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
The following publication Lau, J.K., Vincent, S.J., Collins, M.J. et al. Ocular higher-order aberrations and axial eye growth in young Hong Kong children. Sci Rep 8, 6726 (2018) is available at
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