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http://hdl.handle.net/10397/78875
Title: | Direct optical micropatterning of poly(dimethylsiloxane) for microfluidic devices | Authors: | Gao, SR Tung, WT Wong, DSH Bian, LM Zhang, AP |
Issue Date: | Sep-2018 | Source: | Journal of micromechanics and microengineering, Sept. 2018, v. 28, no. 9, 95011 | Abstract: | Poly(dimethylsiloxane) (PDMS) is one of the most popular polymer materials for microfluidic devices. However, it still remains a challenge to rapidly fabricate PDMS microfluidic devices with micrometer-scale feature sizes. In this paper, we present gray-scale digital photolithography technology for direct patterning of large-area high-resolution PDMS microstructures for biomicrofluidic applications. With the positive- and negative-tone photosensitive PDMS (photoPDMS), we rapidly fabricated various PDMS microstructures with complex geometries by using a one-step patterning process. The positive-tone PDMS was used to pattern large-area microfluidic chips, while the negative-tone PDMS was utilized to fabricate high-resolution on-chip microstructures and components. In particular, a large-area microfluidic chip of 5.5 x 2.8 cm(2) with complex three-dimensional (3D) staggered herringbone mixers was fabricated from the positive-tone PDMS by using a single-step optical exposure process; a small microfluidic chip with a feature size as small as 5 mu m was prepared with the negative-tone PDMS. Furthermore, 3D surface engineering of PDMS microchannels was demonstrated to customize extracellular microenvironments for investigating cell migration. | Keywords: | Digital photolithography Poly(dimethylsiloxane) Microfluidic devices Cell migration |
Publisher: | Institute of Physics Publishing | Journal: | Journal of micromechanics and microengineering | ISSN: | 0960-1317 | DOI: | 10.1088/1361-6439/aac44d | Rights: | © 2018 IOP Publishing Ltd This manuscript version is made available under the CC-BY-NC-ND 4.0 license (https://creativecommons.org/licenses/by-nc-nd/4.0/) The following publication Gao, S., Tung, W. T., Wong, D. S. H., Bian, L., & Zhang, A. P. (2018). Direct optical micropatterning of poly (dimethylsiloxane) for microfluidic devices. Journal of Micromechanics and Microengineering, 28(9), 095011 is available at https://doi.org/10.1088/1361-6439/aac44d |
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Zhang_Direct_Optical_Micropatterning.pdf | Pre-Published version | 1.7 MB | Adobe PDF | View/Open |
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