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Title: Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media
Authors: Yu, Z 
Huangfu, J
Zhao, F
Xia, M
Wu, X
Niu, X
Li, D
Lai, P 
Wang, D
Issue Date: 13-Feb-2018
Source: Scientific reports, 13 Feb. 2018, v. 8, no. 1, 2927, p. 1-8
Abstract: Manipulating and focusing light deep inside biological tissue and tissue-like complex media has been desired for long yet considered challenging. One feasible strategy is through optical wavefront engineering, where the optical scattering-induced phase distortions are time reversed or pre-compensated so that photons travel along different optical paths interfere constructively at the targeted position within a scattering medium. To define the targeted position, an internal guidestar is needed to guide or provide a feedback for wavefront engineering. It could be injected or embedded probes such as fluorescence or nonlinear microspheres, ultrasonic modulation, as well as absorption perturbation. Here we propose to use a magnetically controlled optical absorbing microsphere as the internal guidestar. Using a digital optical phase conjugation system, we obtained sharp optical focusing within scattering media through time-reversing the scattered light perturbed by the magnetic microsphere. Since the object is magnetically controlled, dynamic optical focusing is allowed with a relatively large field-of-view by scanning the magnetic field externally. Moreover, the magnetic microsphere can be packaged with an organic membrane, using biological or chemical means to serve as a carrier. Therefore, the technique may find particular applications for enhanced targeted drug delivery, and imaging and photoablation of angiogenic vessels in tumours.
Publisher: Nature Publishing Group
Journal: Scientific reports 
EISSN: 2045-2322
DOI: 10.1038/s41598-018-21258-4
Rights: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
© The Author(s) 2018
The following publication Yu, Z., Huangfu, J., Zhao, F. et al. Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media. Sci Rep 8, 2927 (2018) is available at
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