Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/76591
Title: | Prediction of radix astragali immunomodulatory effect of CD80 expression from chromatograms by quantitative pattern-activity relationship | Authors: | Ng, MCH Lau, TY Fan, K Xu, QS Poon, J Poon, SK Lam, MK Chau, FT Sze, DY |
Issue Date: | 2017 | Source: | BioMed research international, 2017, 3923865 | Abstract: | The current use of a single chemical component as the representative quality control marker of herbal food supplement is inadequate. In this CD80-Quantitative-Pattern-Activity-Relationship (QPAR) study, we built a bioactivity predictive model that can be applicable for complex mixtures. Through integrating the chemical fingerprinting profiles of the immunomodulating herb Radix Astragali (RA) extracts, and their related biological data of immunological marker CD80 expression on dendritic cells, a chemometric model using the Elastic Net Partial Least Square (EN-PLS) algorithm was established. The EN-PLS algorithm increased the biological predictive capability with lower value of RMSEP (11.66) and higher values of R-p(2) (0.55) when compared to the standard PLS model. This CD80-QPAR platform provides a useful predictive model for unknown RAextract's bioactivities using the chemical fingerprint inputs. Furthermore, this bioactivity prediction platform facilitates identification of key bioactivity-related chemical components within complex mixtures for future drug discovery and understanding of the batch-to-batch consistency for quality clinical trials. | Publisher: | Hindawi Publishing Corporation | Journal: | BioMed research international | ISSN: | 2314-6133 | EISSN: | 2314-6141 | DOI: | 10.1155/2017/3923865 | Rights: | Copyright © 2017 Michelle Chun-har Ng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The following article: Michelle Chun-har Ng, Tsui-yan Lau, Kei Fan, et al., “Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship,” BioMed Research International, vol. 2017, Article ID 3923865, 11 pages, 2017 is available at https://doi.org/10.1155/2017/3923865. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ng_Prediction_radix_astragali.pdf | 2.18 MB | Adobe PDF | View/Open |
Page views
127
Last Week
1
1
Last month
Citations as of Sep 22, 2024
Downloads
99
Citations as of Sep 22, 2024
SCOPUSTM
Citations
5
Citations as of Jun 21, 2024
WEB OF SCIENCETM
Citations
4
Last Week
0
0
Last month
Citations as of Sep 26, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.