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Title: In vitro and in vivo degradation evaluation of Mg-based alloys for biomedical applications
Authors: Wong, SS
Chan, LC 
Lai, CP
Ip, WY
Chau, LH
Issue Date: 2015
Source: Journal of material science and technology research, 14, July 2015, no. 2, p. 7-16
Abstract: Biodegradable metals have attracted interest for implant applications because of the potential to eliminate secondary surgeries. Magnesium-based (Mg-based) alloys are potential candidates. The purpose of this study was to evaluate the in vitro and in vivo degradation performances of two custom-made magnesium-based alloys and to determine whether they are sustainable for further investigation. The performances of Magnesium-Zinc-Manganese (Mg-Zn-Mn) alloys at 5% and 1% zinc levels were compared using a mechanical test, hydrogen evolution test, cell viability (MTT) test, and a short term mice subcutaneous implantation. The results showed that the corrosion resistance of the Mg was improved by alloying. While Mg-5Zn-1Mn was more corrodible compared with Mg-1Zn-1Mn, neither of the alloys presented any adverse effects preliminarily and both were suitable for long-term testing for biomedical applications.
Keywords: Biodegradable
In vivo
Hydrogen gas
Publisher: Avanti Publishers
Journal: Journal of material science and technology research 
ISSN: 2410-4701 (online)
DOI: 10.15377/2410-4701.2015.02.01.2
Rights: © 2015 Wong et al.; Avanti Publishers.
This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The following publication Wong, S. S., Chan, L. C., Lai, C. P. & Chau, L. H. (2015). In vitro and in vivo degradation evaluation of mg-based alloys for biomedical applications. Journal of Material Science and Technology Research, 2, 7-16 is available at
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