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http://hdl.handle.net/10397/7574
| Title: | In vitro and in vivo degradation evaluation of Mg-based alloys for biomedical applications | Authors: | Wong, SS Chan, LC Lai, CP Ip, WY Chau, LH |
Issue Date: | 2015 | Source: | Journal of material science and technology research, 14, July 2015, no. 2, p. 7-16 | Abstract: | Biodegradable metals have attracted interest for implant applications because of the potential to eliminate secondary surgeries. Magnesium-based (Mg-based) alloys are potential candidates. The purpose of this study was to evaluate the in vitro and in vivo degradation performances of two custom-made magnesium-based alloys and to determine whether they are sustainable for further investigation. The performances of Magnesium-Zinc-Manganese (Mg-Zn-Mn) alloys at 5% and 1% zinc levels were compared using a mechanical test, hydrogen evolution test, cell viability (MTT) test, and a short term mice subcutaneous implantation. The results showed that the corrosion resistance of the Mg was improved by alloying. While Mg-5Zn-1Mn was more corrodible compared with Mg-1Zn-1Mn, neither of the alloys presented any adverse effects preliminarily and both were suitable for long-term testing for biomedical applications. | Keywords: | Biodegradable Magnesium In vivo Hydrogen gas Zinc |
Publisher: | Avanti Publishers | Journal: | Journal of material science and technology research | ISSN: | 2410-4701 (online) | DOI: | 10.15377/2410-4701.2015.02.01.2 | Rights: | © 2015 Wong et al.; Avanti Publishers. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. The following publication Wong, S. S., Chan, L. C., Lai, C. P. & Chau, L. H. (2015). In vitro and in vivo degradation evaluation of mg-based alloys for biomedical applications. Journal of Material Science and Technology Research, 2, 7-16 is available at http://dx.doi.org/10.15377/2410-4701.2015.02.01.2 |
| Appears in Collections: | Journal/Magazine Article |
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| Wong_Vitro_Degradation_Evaluation.pdf | 3.08 MB | Adobe PDF | View/Open |
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