Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/7445
DC Field | Value | Language |
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dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Gu, YJ | - |
dc.creator | Cheng, J | - |
dc.creator | Jin, J | - |
dc.creator | Cheng, SH | - |
dc.creator | Wong, WT | - |
dc.date.accessioned | 2014-12-19T07:05:03Z | - |
dc.date.available | 2014-12-19T07:05:03Z | - |
dc.identifier.issn | 1176-9114 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/7445 | - |
dc.language.iso | en | en_US |
dc.publisher | Dove Medical Press | en_US |
dc.rights | © 2011 Gu et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | en_US |
dc.rights | The following publication: Gu, Y. J., Cheng, J., Jin, J., Cheng, S. H., & Wong, W. T. (2011). Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells. International journal of nanomedicine, 6, 2889-98 is available at http://dx.doi.org/10.2147/IJN.S25162 | en_US |
dc.title | Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells. | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 2889 | en_US |
dc.identifier.epage | 2898 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.doi | 10.2147/IJN.S25162 | en_US |
dcterms.abstract | Single-walled carbon nanotubes (SWNTs) have been identified as an efficient drug carrier. Here a controlled drug-delivery system based on SWNTs coated with doxorubicin (DOX) through hydrazone bonds was developed, because the hydrazone bond is more sensitive to tumor microenvironments than other covalent linkers. The SWNTs were firstly stabilized with polyethylene glycol (H(2)N-PEG-NH(2)). Hydrazinobenzoic acid (HBA) was then covalently attached on SWNTs via carbodiimide-activated coupling reaction to form hydrazine-modified SWNTs. The anticancer drug DOX was conjugated to the HBA segments of SWNT using hydrazine as the linker. The resulting hydrazone bonds formed between the DOX molecules and the HBA segments of SWNTs are acid cleavable, thereby providing a strong pH-responsive drug release, which may facilitate effective DOX release near the acidic tumor microenvironment and thus reduce its overall systemic toxicity. The DOX-loaded SWNTs were efficiently taken up by HepG2 tumor cells, and DOX was released intracellularly, as revealed by MTT assay and confocal microscope observations. Compared with SWNT-DOX conjugate formed by supramolecular interaction, the SWNT-HBA-DOX featured high weight loading and prolonged release of DOX, and thus improved its cytotoxicity against cancer cells. This study suggests that while SWNTs have great potential as a drug carrier, the efficient formulation strategy requires further study. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | International journal of nanomedicine, 2011, v. 6, p. 2889-2898 | - |
dcterms.isPartOf | International journal of nanomedicine | - |
dcterms.issued | 2011 | - |
dc.identifier.isi | WOS:000297687500001 | - |
dc.identifier.scopus | 2-s2.0-84859134575 | - |
dc.identifier.pmid | 22131835 | - |
dc.identifier.eissn | 1178-2013 | en_US |
dc.identifier.rosgroupid | r58972 | - |
dc.description.ros | 2011-2012 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201811_a bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Gu_development_evaluation_pHresponsive.pdf | 1.28 MB | Adobe PDF | View/Open |
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