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Title: MiR-30 family potentially targeting PI3K-SIAH2 predicted interaction network represents a novel putative theranostic panel in non-small cell lung cancer
Authors: Chan, LWC 
Wang, FF 
Meng, F 
Wang, LL 
Wong, SCC 
Yang, SJ
Cho, WCS
Issue Date: 2-Feb-2017
Source: Frontiers in genetics, 2 Feb. 2017, v. 8, 8, p. 1-5
Abstract: Non-small cell lung cancer (NSCLC) comprises about 84% of all lung cancers. Many treatment options are available but the survival rate is still very low due to drug resistance. It has been found that phosphoinositide-3-kinase (PI3K) affects sensitivity to tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib. Expression level of seven in absentia homolog 2 (SIAH2), an E3 ubiquitin-protein ligase, is upregulated in NSCLC and correlated with tumor grade. However, the relationship between P13K and SIAH2 remains unclear and therefore it is not known whether they can act as treatment co-targets and theranostic dual markers for overcoming TKI resistance. It is worthy to note that P13K and SIAH2 are potentially regulated by a common group of microRNAs in miR-30 family. Our bioinformatics analyses showed upregulated SIAH2 expression in NSCLC based on mass spectrometry data, explored its indirect interaction with P13K and predicted their targeting microRNAs in common. We have also explored the potential role of miR-30 family in the modulation of PI3K-SIAH2 interaction in NSCLC.
Keywords: PI3K
Non-small cell lung cancer
Publisher: Frontiers Research Foundation
Journal: Frontiers in genetics 
ISSN: 1664-8021
DOI: 10.3389/fgene.2017.00008
Rights: Copyright © 2017 Chan, Wang, Meng, Wang, Wong, Au, Yang and Cho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Chan LWC, Wang F, Meng F, Wang L, Wong SCC, Au JSK, Yang S and Cho WCS (2017) MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung Cancer. Front. Genet. 8:8,1-5 is available at
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