Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70903
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dc.contributorDepartment of Rehabilitation Sciences-
dc.creatorChan, JNM-
dc.creatorLee, JCD-
dc.creatorLee, SSP-
dc.creatorHui, KKY-
dc.creatorChan, AHL-
dc.creatorFung, TKH-
dc.creatorSanchez-Vidana, DI-
dc.creatorLau, BWM-
dc.creatorNgai, SPC-
dc.date.accessioned2017-12-28T06:18:27Z-
dc.date.available2017-12-28T06:18:27Z-
dc.identifier.issn1662-5153en_US
dc.identifier.urihttp://hdl.handle.net/10397/70903-
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.rightsCopyright © 2017 Chan, Lee, Lee, Hui, Chan, Fung, Sánchez-Vidaña, Lau and Ngai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Chan JN-M, Lee JC-D, Lee SSP, Hui KKY, Chan AHL, Fung TK-H, Sánchez-Vidaña DI, Lau BW-M and Ngai SP-C (2017) Interaction Effect of Social Isolation and High Dose Corticosteroid on Neurogenesis and Emotional Behavior. Front. Behav. Neurosci. 11:18,1-10 is available at https://dx.doi.org/10.3389/fnbeh.2017.00018en_US
dc.subjectNeurogenesisen_US
dc.subjectHippocampusen_US
dc.subjectSocial isolationen_US
dc.subjectCorticosteroneen_US
dc.subjectEmotionen_US
dc.subjectMooden_US
dc.titleInteraction effect of social isolation and high dose corticosteroid on neurogenesis and emotional behavioren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.volume11en_US
dc.identifier.doi10.3389/fnbeh.2017.00018en_US
dcterms.abstractHypercortisolemia is one of the clinical features found in depressed patients. This clinical feature has been mimicked in animal studies via application of exogenous corticosterone (CORT). Previous studies suggested that CORT can induce behavioral disturbance in anxious-depressive like behavior, which is associated with suppressed neurogenesis. Hippocampal neurogenesis plays an important role in adult cognitive and behavioral regulation. Its suppression may thus lead to neuropsychiatric disorders. Similar to the effects of CORT on the animals' depression-like behaviors and neurogenesis, social deprivation has been regarded as one factor that predicts poor prognosis in depression. Furthermore, social isolation is regarded as a stressor to social animals including experimental rodents. Hence, this study aims to examine if social isolation would induce further emotional or anxiety-like behavior disturbance and suppress neurogenesis in an experimental model that was repeatedly treated with CORT. Sprague-Dawley rats were used in this study to determine the effects of different housing conditions, either social isolated or group housing, in vehicle-treated control and CORT-treated animals. Forced swimming test (FST), open field test (OFT) and social interaction test (SIT) were used to assess depression-like, anxiety-like and social behaviors respectively. Immunohistochemistry was performed to quantify the number of proliferative cells and immature neurons in the hippocampus, while dendritic maturation of immature neurons was analyzed by Sholl analysis. Social isolation reduced latency to immobility in FST. Furthermore, social isolation could significantly reduce the ratio of doublecortin and bromodeoxyuridine (BrdU) positive cells of the neurogenesis assay under CORT-treated condition. The current findings suggested that the behavioral and neurological effect of social isolation is dependent on the condition of hypercortisolemia. Furthermore, social isolation may possibly augment the signs and symptoms of depressed patients with potential alteration in neurogenesis.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationFrontiers in behavioral neuroscience, 21. Feb. 2017, v. 11, 18, p. 1-10-
dcterms.isPartOfFrontiers in behavioral neuroscience-
dcterms.issued2017-02-21-
dc.identifier.isiWOS:000394698400001-
dc.identifier.pmid28270754-
dc.identifier.ros2016001311-
dc.identifier.artn18en_US
dc.identifier.rosgroupid2016001293-
dc.description.ros2016-2017 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validatebcrcen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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