Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70607
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dc.contributorDepartment of Biomedical Engineeringen_US
dc.creatorDong, Yen_US
dc.creatorJin, Gen_US
dc.creatorJi, Cen_US
dc.creatorHe, Ren_US
dc.creatorLin, Men_US
dc.creatorZhao, Xen_US
dc.creatorLi, Aen_US
dc.creatorLu, TJen_US
dc.creatorXu, Fen_US
dc.date.accessioned2017-12-28T06:17:30Z-
dc.date.available2017-12-28T06:17:30Z-
dc.identifier.issn1742-7061en_US
dc.identifier.urihttp://hdl.handle.net/10397/70607-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_US
dc.rights© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Dong, Y., Jin, G., Ji, C., He, R., Lin, M., Zhao, X., ... & Xu, F. (2017). Non-invasive tracking of hydrogel degradation using upconversion nanoparticles. Acta biomaterialia, 55, 410-419 is available at https://doi.org/10.1016/j.actbio.2017.04.016en_US
dc.subjectHydrogelsen_US
dc.subjectDegradationen_US
dc.subjectUpconversion nanoparticlesen_US
dc.subjectNon-invasive trackingen_US
dc.titleNon-invasive tracking of hydrogel degradation using upconversion nanoparticlesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage410en_US
dc.identifier.epage419en_US
dc.identifier.volume55en_US
dc.identifier.doi10.1016/j.actbio.2017.04.016en_US
dcterms.abstractTracking the distribution and degradation of hydrogels in vivo is important for various applications including tissue engineering and drug delivery. Among various imaging modalities, fluorescence imaging has attracted intensive attention due to their high sensitivity, low cost and easy operation. Particularly, upconversion nanoparticles (UCNPs) that emit visible lights upon near-infrared (NIR) light excitation as tracking probes are promising in deciphering the fate of hydrogels after transplantation. Herein, we reported a facile and non-invasive in vivo hydrogel tracking method using UCNPs, where the degradation of hydrogels was determined using the decrease in fluorescence intensity from the UCNPs encapsulated in the hydrogels. We found that the change in the fluorescence intensity from the UCNPs was well consistent with that of the fluorescein isothiocyanate (FITC) covalently conjugated to hydrogels and also with the weight change of the hydrogels, suggesting the accuracy of the UCNPs in tracking the degradation of hydrogels. Furthermore, the in vivo fluorescence signals were only observed from the UCNPs instead of FITC after implantation for 7 days due to the deep tissue penetration of UCNPs, demonstrating the capability of UCNPs in longitudinal, consecutive and non-invasive monitoring the in vivo degradation of hydrogels without causing any damage to the major organs (heart, lung, liver and kidney) of model rats. This study thus paves the way for monitoring the in vivo behaviors of biomimetic materials via deep tissue imaging with great clinical translation potentials. Statement of Significance Long-term noninvasive in vivo tracking of the distribution and degradation of biodegradable hydrogels using fluorescent probes is important in tissue regeneration and drug delivery. Unlike the widely used fluorescent dyes and quantum dots (QDs) that suffer from photobleaching and undesired toxicity, upconversion nanoparticles (UCNPs) with high stability, deep tissue penetration as tracking probes are promising in deciphering the fate of hydrogels after transplantation. Herein, we reported a noninvasive in vivo hydrogel tracking method using UCNPs and found that the fluorescence intensity change from the UCNPs was well consistent with the weight change of the hydrogels, suggesting the accuracy of UCNPs in tracking hydrogel degradation. This study provides inspirations on developing advanced NIR light regulated probes with great clinical translation potentials.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationActa biomaterialia,17 June 2017, v. 55, p. 410-419en_US
dcterms.isPartOfActa biomaterialiaen_US
dcterms.issued2017-06-17-
dc.identifier.isiWOS:000403414500032-
dc.identifier.pmid28428038-
dc.identifier.ros2016004317-
dc.identifier.eissn1878-7568en_US
dc.identifier.rosgroupid2016004235-
dc.description.ros2016-2017 > Academic research: refereed > Publication in refereed journalen_US
dc.description.validatebcrcen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberBME-0202-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS6741619-
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