Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/65569
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Wang, F | - |
dc.creator | Meng, F | - |
dc.creator | Wang, L | - |
dc.creator | Wong, CS | - |
dc.creator | Cho, WCS | - |
dc.creator | Chan, LWC | - |
dc.date.accessioned | 2017-05-22T02:08:51Z | - |
dc.date.available | 2017-05-22T02:08:51Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/65569 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Research Foundation | en_US |
dc.rights | Copyright © 2016 Wang, Meng, Wang, Wong, Cho and Chan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights | The following publication Wang F, Meng F, Wang L, Wong SCC, Cho WCS and Chan LWC (2016) Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer. Front. Genet. 7:173,1-8 is available at https://dx.doi.org/10.3389/fgene.2016.00173 | en_US |
dc.subject | Alternative tyrosine kinase receptors | en_US |
dc.subject | EGFR | en_US |
dc.subject | MicroRNA | en_US |
dc.subject | Multiple linear regression | en_US |
dc.subject | Non-small cell lung cancer | en_US |
dc.subject | Support vector regression model | en_US |
dc.title | Associations of mRNA:microRNA for the shared downstream molecules of EGFR and alternative tyrosine kinase receptors in non-small cell lung cancer | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 13 | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.doi | 10.3389/fgene.2016.00173 | en_US |
dcterms.abstract | Lung cancer is the top cancer killer worldwide with high mortality rate. Majority belong to non-small cell lung cancers (NSCLCs). The epidermal growth factor receptor (EGFR) has been broadly explored as a drug target for therapy. However, the drug responses are not durable due to the acquired resistance. MicroRNAs (miRNAs) are small non-coding and endogenous molecules that can inhibit mRNA translation initiation and degrade mRNAs. We wonder if some downstream molecules shared by EGFR and the other tyrosine kinase receptors (TKRs) further transduce the signals alternatively, and some miRNAs play the key roles in affecting the expression of these downstream molecules. In this study, we investigated the mRNA:miRNA associations for the direct EGFR downstream molecules in the EGFR signaling pathway shared with the other TKRs, including c-MET (hepatocyte growth factor receptor), Ron (a protein tyrosine kinase related to c-MET), PDGFR (platelet-derived growth factor receptor), and IGF-1R (insulin-like growth factor receptor-1). The multiple linear regression and support vector regression (SVR) models were used to discover the statistically significant and the best weighted miRNAs regulating the mRNAs of these downstream molecules. These two models revealed the similar mRNA:miRNA associations. It was found that the miRNAs significantly affecting the mRNA expressions in the multiple regression model were also those with the largest weights in the SVR model. To conclude, we effectively identified a list of meaningful mRNA:miRNA associations: phospholipase C, gamma 1 (PLCG1) with miR-34a, phosphoinositide-3-kinase, regulatory subunit 2 (PIK3R2) with miR-30a-5p, growth factor receptor-bound protein 2 (GRB2) with miR-27a, and Janus kinase 1 (JAK1) with miR-302b and miR-520e. These associations could make great contributions to explore new mechanism in NSCLCs. These candidate miRNAs may be regarded as the potential drug targets for treating NSCLCs with acquired drug resistance. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Frontiers in genetics, 13 Oct. 2016, v. 7, 173, p. 1-8 | - |
dcterms.isPartOf | Frontiers in genetics | - |
dcterms.issued | 2016-10-13 | - |
dc.identifier.scopus | 2-s2.0-84997236552 | - |
dc.identifier.ros | 2016000206 | - |
dc.identifier.eissn | 1664-8021 | en_US |
dc.identifier.artn | 173 | en_US |
dc.identifier.rosgroupid | 2016000205 | - |
dc.description.ros | 2016-2017 > Academic research: refereed > Publication in refereed journal | en_US |
dc.description.validate | 201804_a bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Wang_MRNA_microRNA_Shared.pdf | 1.21 MB | Adobe PDF | View/Open |
Page views
154
Last Week
1
1
Last month
Citations as of Sep 22, 2024
Downloads
75
Citations as of Sep 22, 2024
SCOPUSTM
Citations
16
Last Week
0
0
Last month
Citations as of Sep 26, 2024
WEB OF SCIENCETM
Citations
18
Last Week
0
0
Last month
Citations as of Sep 26, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.