Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/65360
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | - |
dc.creator | Ye, W | - |
dc.creator | Xu, Y | - |
dc.creator | Zheng, L | - |
dc.creator | Zhang, Y | - |
dc.creator | Yang, M | - |
dc.creator | Sun, P | - |
dc.date.accessioned | 2017-05-22T02:08:27Z | - |
dc.date.available | 2017-05-22T02:08:27Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/65360 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Ye, W., Xu, Y., Zheng, L., Zhang, Y., Yang, M., & Sun, P. (2016). A nanoporous alumina membrane based electrochemical biosensor for histamine determination with biofunctionalized magnetic nanoparticles concentration and signal amplification. Sensors, 16(10), (Suppl. ), 1767, - is available at https://dx.doi.org/10.3390/s16101767 | en_US |
dc.subject | Electrochemical biosensor | en_US |
dc.subject | Histamine | en_US |
dc.subject | Magnetic nanoparticles | en_US |
dc.subject | Nanoporous alumina membrane | en_US |
dc.title | A nanoporous alumina membrane based electrochemical biosensor for histamine determination with biofunctionalized magnetic nanoparticles concentration and signal amplification | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 10 | - |
dc.identifier.doi | 10.3390/s16101767 | - |
dcterms.abstract | Histamine is an indicator of food quality and indispensable in the efficient functioning of various physiological systems. Rapid and sensitive determination of histamine is urgently needed in food analysis and clinical diagnostics. Traditional histamine detection methods require qualified personnel, need complex operation processes, and are time-consuming. In this study, a biofunctionalized nanoporous alumina membrane based electrochemical biosensor with magnetic nanoparticles (MNPs) concentration and signal amplification was developed for histamine determination. Nanoporous alumina membranes were modified by anti-histamine antibody and integrated into polydimethylsiloxane (PDMS) chambers. The specific antibody modified MNPs were used to concentrate histamine from samples and transferred to the antibody modified nanoporous membrane. The MNPs conjugated to histamine were captured in the nanopores via specific reaction between histamine and anti-histamine antibody, resulting in a blocking effect that was amplified by MNPs in the nanopores. The blockage signals could be measured by electrochemical impedance spectroscopy across the nanoporous alumina membrane. The sensing platform had great sensitivity and the limit of detection (LOD) reached as low as 3 nM. This biosensor could be successfully applied for histamine determination in saury that was stored in frozen conditions for different hours, presenting a potentially novel, sensitive, and specific sensing system for food quality assessment and safety support. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Sensors, Oct. 2016, v. 16, no. 10, 1767, p. 1-12 | - |
dcterms.isPartOf | Sensors | - |
dcterms.issued | 2016 | - |
dc.identifier.isi | WOS:000386131600215 | - |
dc.identifier.scopus | 2-s2.0-84992520090 | - |
dc.identifier.ros | 2016000394 | - |
dc.identifier.eissn | 1424-8220 | - |
dc.identifier.artn | 1767 | - |
dc.identifier.rosgroupid | 2016000393 | - |
dc.description.ros | 2016-2017 > Academic research: refereed > Publication in refereed journal | - |
dc.description.validate | 201804_a bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Ye_Nanoporous_Alumina_Membrane.pdf | 2.27 MB | Adobe PDF | View/Open |
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