Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/6518
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorMa, DL-
dc.creatorChan, DSH-
dc.creatorFu, WC-
dc.creatorHe, HZ-
dc.creatorYang, H-
dc.creatorYan, SC-
dc.creatorLeung, CH-
dc.date.accessioned2014-12-11T08:24:03Z-
dc.date.available2014-12-11T08:24:03Z-
dc.identifier.urihttp://hdl.handle.net/10397/6518-
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rights© 2012 Ma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rightsThe website of Creative Commons Attribution 3.0 Unported (CC by 3.0) is located at <http://creativecommons.org/licenses/by/3.0/>en_US
dc.subjectPromoter regionen_US
dc.subjectDown-regulationen_US
dc.subjectLiganden_US
dc.subjectRecognitionen_US
dc.subjectIdentificationen_US
dc.subjectStabilizationen_US
dc.subjectTranscriptionen_US
dc.subjectTargeten_US
dc.titleDiscovery of a natural product-like c-myc G-quadruplex DNA groove-binder by molecular dockingen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage8-
dc.identifier.volume7-
dc.identifier.issue8-
dc.identifier.doi10.1371/journal.pone.0043278-
dcterms.abstractThe natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by its ability to inhibit Taq polymerase-mediated DNA extension and c-myc expression in vitro, demonstrating that 1 is able to control c-myc gene expression at the transcriptional level presumably through the stabilization of the c-myc promoter G-quadruplex. Furthermore, the interaction between carbamide analogues and the c-myc G-quadruplex was also investigated by in vitro experiments in order to generate a brief structure-activity relationship (SAR) for the observed potency of carbamide 1.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationPLoS one, 17 Aug., 2012, v. 7, no. 8, e43278, p. 1-8-
dcterms.isPartOfPLoS one-
dcterms.issued2012-08-17-
dc.identifier.isiWOS:000308063700073-
dc.identifier.scopus2-s2.0-84865086964-
dc.identifier.pmid22912844-
dc.identifier.eissn1932-6203-
dc.identifier.rosgroupidr67411-
dc.description.ros2012-2013 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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