Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/6518
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Ma, DL | - |
dc.creator | Chan, DSH | - |
dc.creator | Fu, WC | - |
dc.creator | He, HZ | - |
dc.creator | Yang, H | - |
dc.creator | Yan, SC | - |
dc.creator | Leung, CH | - |
dc.date.accessioned | 2014-12-11T08:24:03Z | - |
dc.date.available | 2014-12-11T08:24:03Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/6518 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2012 Ma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The website of Creative Commons Attribution 3.0 Unported (CC by 3.0) is located at <http://creativecommons.org/licenses/by/3.0/> | en_US |
dc.subject | Promoter region | en_US |
dc.subject | Down-regulation | en_US |
dc.subject | Ligand | en_US |
dc.subject | Recognition | en_US |
dc.subject | Identification | en_US |
dc.subject | Stabilization | en_US |
dc.subject | Transcription | en_US |
dc.subject | Target | en_US |
dc.title | Discovery of a natural product-like c-myc G-quadruplex DNA groove-binder by molecular docking | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 8 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 8 | - |
dc.identifier.doi | 10.1371/journal.pone.0043278 | - |
dcterms.abstract | The natural product-like carbamide (1) has been identified as a stabilizer of the c-myc G-quadruplex through high-throughput virtual screening. NMR and molecular modeling experiments revealed a groove-binding mode for 1. The biological activity of 1 against the c-myc G-quadruplex was confirmed by its ability to inhibit Taq polymerase-mediated DNA extension and c-myc expression in vitro, demonstrating that 1 is able to control c-myc gene expression at the transcriptional level presumably through the stabilization of the c-myc promoter G-quadruplex. Furthermore, the interaction between carbamide analogues and the c-myc G-quadruplex was also investigated by in vitro experiments in order to generate a brief structure-activity relationship (SAR) for the observed potency of carbamide 1. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 17 Aug., 2012, v. 7, no. 8, e43278, p. 1-8 | - |
dcterms.isPartOf | PLoS one | - |
dcterms.issued | 2012-08-17 | - |
dc.identifier.isi | WOS:000308063700073 | - |
dc.identifier.scopus | 2-s2.0-84865086964 | - |
dc.identifier.pmid | 22912844 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.rosgroupid | r67411 | - |
dc.description.ros | 2012-2013 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Ma_Natural_Product-like_DNA.pdf | 698.96 kB | Adobe PDF | View/Open |
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