Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/61251
Title: | Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity | Authors: | Chung, PY Tang, JCO Cheng, CH Bian, ZX Wong, WY Lam, KH Chui, CH |
Issue Date: | 2016 | Source: | SpringerPlus, 2016, v. 5, 271, p. 1-6 | Abstract: | Background: Candida susceptibility commonly occurs in breast cancer patients. Of which, Candida albicans is considered as a common pathogen causing candidiasis. Martinella iquitosensis (Bignoniaceae) is one of the species belonged to Martinella, distributed widely in Amazon basin. Its root extract yielded two complex substituted tetrahydroquinolines, Martinelline and Martinellic acid which were the first natural non-peptide bradykinin receptor antagonists identified. Findings: In this study, a novel martinelline type analogue, named 2,3,3a,4,5,9b-hexahydro-8-phenoxy-4-(pyridin-2-yl)furo[3,2-c]quinoline, was synthesized and its preliminary anticancer activity and antifungal potential were investigated. This compound showed potential anticancer activity against MDAMB-231 breast cancer cells. Meanwhile it could enhance the fungistatic activity of miconazole against Candida albicans. Conclusions: These findings provide an implication for the continue investigation and development of martinelline type analogues as therapeutic agents in the future. |
Keywords: | Biological activity Candida albicans Hexahydrofuro[3,2-c]quinoline Martinelline type analogue |
Publisher: | SpringerOpen | Journal: | SpringerPlus | ISSN: | 2193-1801 | DOI: | 10.1186/s40064-016-1890-5 | Rights: | © 2016 Chung etal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The following publication Chung, P. Y., Tang, J. C. O., Cheng, C. H., Bian, Z. X., Wong, W. Y., Lam, K. H., & Chui, C. H. (2016). Synthesis of hexahydrofuro[3,2-c]quinoline, a martinelline type analogue and investigation of its biological activity. Springerplus, 5, 271, 1-6 is available at https://dx.doi.org/10.1186/s40064-016-1890-5 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Chung_Synthesis_Hexahydrofuro_32-C_Quinoline.pdf | 1.14 MB | Adobe PDF | View/Open |
Page views
141
Last Week
3
3
Last month
Citations as of Oct 13, 2024
Downloads
89
Citations as of Oct 13, 2024
SCOPUSTM
Citations
15
Last Week
0
0
Last month
Citations as of Oct 17, 2024
WEB OF SCIENCETM
Citations
14
Last Week
0
0
Last month
Citations as of Oct 17, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.