Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/54601
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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorSánchez-Vidaña, DIen_US
dc.creatorChan, NMJen_US
dc.creatorChan, AHLen_US
dc.creatorHui, KKYen_US
dc.creatorLee, Sen_US
dc.creatorChan, HYen_US
dc.creatorLaw, YSen_US
dc.creatorSze, MYen_US
dc.creatorTsui, WCSen_US
dc.creatorFung, TKHen_US
dc.creatorLau, BWMen_US
dc.creatorLai, CYYen_US
dc.date.accessioned2016-08-17T02:05:56Z-
dc.date.available2016-08-17T02:05:56Z-
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10397/54601-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2016 IBRO. Published by Elsevier Ltd. All rights reserved.en_US
dc.rights© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Sánchez-Vidaña, D. I., Chan, N. M. J., Chan, A. H., Hui, K. K., Lee, S., Chan, H. Y., ... & Lai, C. Y. (2016). Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior. Neuroscience, 333, 65-77 is available at https://doi.org/10.1016/j.neuroscience.2016.07.005.en_US
dc.subjectOxytocinen_US
dc.subjectHippocampal cell proliferationen_US
dc.subjectNeurogenesisen_US
dc.subjectDendritic complexityen_US
dc.subjectDepression-like behaviorsen_US
dc.subjectAnxiety-like behaviorsen_US
dc.titleRepeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavioren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage65en_US
dc.identifier.epage77en_US
dc.identifier.volume333en_US
dc.identifier.doi10.1016/j.neuroscience.2016.07.005en_US
dcterms.abstractRewarding social behaviors including positive social interactions and sexual behaviors are shown to regulate adult neurogenesis, but the underlying biological mechanisms remain elusive. Oxytocin, a neurohypophysial hormone secreted after exposure to social interaction or sexual behaviors, has a profound role in the formation of social bonding and regulation of emotional distress. While the acute effect of oxytocin was usually studied, relatively scarce evidence showed the behavioral consequence of repeated oxytocin treatment. The purpose of the current study was to investigate the effect of repeated oxytocin treatment on hippocampal cell proliferation, dendritic maturation of new born neurons and social/emotional behaviors. Adult male Sprague–Dawley rats received treatment with either vehicle or oxytocin (1 mg/kg) daily for two weeks. Behavioral tests revealed that oxytocin increased social behaviors and reduced the anxiety- and depression-like behaviors. Cell proliferation, differentiation and the dendritic complexity of new born neurons in the hippocampus were promoted by oxytocin treatment. Depression- and anxiety-like behaviors were induced by repeated treatment of corticosterone (40 mg/kg) for two weeks while oxytocin treatment reversed the behavioral disturbances. Suppression of cell proliferation caused by corticosterone was reverted by oxytocin treatment in which cell proliferation, cell differentiation, and dendritic complexity increased. The present findings reveal that oxytocin not only enhances cell proliferation, but also promotes the development of the new neurons which is associated with the induction of positive emotional and social behaviors. The results also suggest that oxytocin may be a potential therapeutic agent for treatment of emotional and social dysfunction.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationNeuroscience,1 Oct. 2016, v. 333, p. 65-77en_US
dcterms.isPartOfNeuroscienceen_US
dcterms.issued2016-10-01-
dc.identifier.rosgroupid2015001352-
dc.description.ros2015-2016 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberRS-0437-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextthe Large Equipment Fund, The Hong Kong Polytechnic Universit ; ECS, University Grant Council, H.K. (0112876) to Lau B.Wen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS6662124-
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