Discriminating Astragali Radix from its adulterants using HPLC coupled with chemometric clustering techniques

Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/5295

Title:	Discriminating Astragali Radix from its adulterants using HPLC coupled with chemometric clustering techniques
Authors:	Dong, WW Au, D Cao, XW Li, XB Yang, D
Issue Date:	2011
Source:	Journal of food and drug analysis, 2011, v. 19, no. 4, p. 495-501
Abstract:	A simple high-performance liquid chromatography (HPLC) method coupled with principal component analysis (PCA) and hierarchical cluster analysis (HCA) was developed for distinguishing Astragali Radix from its adulterants. Five species, including A. membranaceus var. mongolicus, A. membranaceus, H. polybotrys, A. chrysopterus and A. ernestii, were analyzed by this method. At the same time, four major bioactive isoflavonoids, namely calycosin-7-O-D-glucopyranoside, ononin, calycosin and formononetin, were simultaneously determined in Astragali Radix. This method was proven to have good precision, repeatability, stability and recovery. It was successfully applied to distinguish Astragali Radix from its adulterants species and can be used for the quality control of Astragali Radix.
Keywords:	Astragali Radix Isoflavonoids HPLC Principle component analysis Hierarchical cluster analysis
Publisher:	Food and Drug Administration, Department of Health, Executive Yuan
Journal:	Journal of food and drug analysis
ISSN:	1021-9498
Rights:	Copyright 2012, FDA. All Rights Reserved. Posted with permission of the publisher.
Appears in Collections:	Journal/Magazine Article

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