Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/5117
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorSong, YQ-
dc.creatorHo, DWH-
dc.creatorKarppinen, J-
dc.creatorKao, PYP-
dc.creatorFan, BJ-
dc.creatorLuk, KDK-
dc.creatorYip, SP-
dc.creatorLeong, JCY-
dc.creatorCheah, KSE-
dc.creatorSham, PC-
dc.creatorChan, D-
dc.creatorCheung, KMC-
dc.date.accessioned2014-12-11T08:28:04Z-
dc.date.available2014-12-11T08:28:04Z-
dc.identifier.issn1471-2350-
dc.identifier.urihttp://hdl.handle.net/10397/5117-
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.rights© 2008 Song et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectGenetic polymorphismsen_US
dc.subjectMedical geneticsen_US
dc.subjectLeucocytesen_US
dc.subjectMetalloproteinasesen_US
dc.subjectExtracellular matrixen_US
dc.titleAssociation between promoter -1607 polymorphism of MMPI and Lumbar Disc Disease in Southern Chineseen_US
dc.typeJournal/Magazine Articleen_US
dc.description.otherinformationAuthor name used in this publication: Pak Shamen_US
dc.identifier.spage1-
dc.identifier.epage6-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.doi10.1186/1471-2350-9-38-
dcterms.abstractBackground: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix of the intervertebral disc. A SNP for guanine insertion/deletion (G/D), the -1607 promoter polymorphism, of the MMP1 gene was found significantly affecting promoter activity and corresponding transcription level. Hence it is a good candidate for genetic studies in DDD.-
dcterms.abstractMethods: Southern Chinese volunteers between 18 and 55 years were recruited from the population. DDD in the lumbar spine was defined by MRI using Schneiderman's classification. Genomic DNA was isolated from the leukocytes and genotyping was performed using the Sequenom® platform. Association and Hardy-Weinberg equilibrium checking were assessed by Chi-square test and Mann-Whitney U test.-
dcterms.abstractResults: Our results showed substantial evidence of association between -1607 promoter polymorphism of MMP1 and DDD in the Southern Chinese subjects. D allelic was significantly associated with DDD (p value = 0.027, odds ratio = 1.41 with 95% CI = 1.04–1.90) while Genotypic association on the presence of D allele was also significantly associated with DDD (p value = 0.046, odds ratio = 1.50 with 95% CI = 1.01–2.24). Further age stratification showed significant genotypic as well as allelic association in the group of over 40 years (genotypic: p value = 0.035, odds ratio = 1.617 with 95% CI = 1.033–2.529; allelic: p value = 0.033, odds ratio = 1.445 with 95% CI = 1.029–2.029). Disc bulge, annular tears and the Schmorl's nodes were not associated with the D allele.-
dcterms.abstractConclusion: We demonstrated that individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only. Further association was identified in individuals over 40 years of age. Disc bulge, annular tear as well as Schmorl's nodes were not associated with this polymorphism.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBMC medical genetics, 28 Apr. 2008, v. 9, 38, p. 1-6-
dcterms.isPartOfBMC medical genetics-
dcterms.issued2008-04-28-
dc.identifier.isiWOS:000256300800001-
dc.identifier.scopus2-s2.0-43849088196-
dc.identifier.pmid18439317-
dc.identifier.rosgroupidr37532-
dc.description.ros2007-2008 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Song_Association_promoter_polymorphism.pdf290.52 kBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

127
Last Week
0
Last month
Citations as of Mar 24, 2024

Downloads

58
Citations as of Mar 24, 2024

SCOPUSTM   
Citations

51
Last Week
0
Last month
2
Citations as of Mar 28, 2024

WEB OF SCIENCETM
Citations

43
Last Week
0
Last month
2
Citations as of Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.