Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/5115
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dc.contributorDepartment of Health Technology and Informatics-
dc.creatorLeung, KH-
dc.creatorYip, SP-
dc.creatorWong, WS-
dc.creatorYiu, LS-
dc.creatorChan, KK-
dc.creatorLai, WM-
dc.creatorChow, EYD-
dc.creatorLin, CK-
dc.creatorYam, WC-
dc.creatorChan, KS-
dc.date.accessioned2014-12-11T08:24:15Z-
dc.date.available2014-12-11T08:24:15Z-
dc.identifier.issn1471-2334-
dc.identifier.urihttp://hdl.handle.net/10397/5115-
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.rights© 2007 Leung et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.subjectTuberculosisen_US
dc.subjectMedical geneticsen_US
dc.subjectGenetic polymorphismsen_US
dc.subjectGenetic markersen_US
dc.subjectChinaen_US
dc.titleSex- and age-dependent association of SLCllAl polymorphisms with tuberculosis in Chinese : a case control studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1-
dc.identifier.epage9-
dc.identifier.volume7-
dc.identifier.issue1-
dc.identifier.doi10.1186/1471-2334-7-19-
dcterms.abstractBackground: Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphisms and TB.-
dcterms.abstractMethods: A case-control study was conducted. In total, 278 pulmonary TB patients and 282 sex- and age-matched controls without TB were recruited. All subjects were ethnic Chinese. On the basis of linkage disequilibrium pattern, three genetic markers from SLC11A1 and one from the nearby IL8RB locus were selected and examined for association with TB susceptibility. These markers were genotyped using single strand conformation polymorphism analysis or fragment analysis of amplified products.-
dcterms.abstractResults: Statistically significant differences in allele (P = 0.0165, OR = 1.51) and genotype (P = 0.0163, OR = 1.59) frequencies of the linked markers SLC6a/b (classically called D543N and 3'UTR) of the SLC11A1 locus were found between patients and controls. With stratification by sex, positive associations were identified in the female group for both allele (P = 0.0049, OR = 2.54) and genotype (P = 0.0075, OR = 2.74)frequencies. With stratification by age, positive associations were demonstrated in the young age group (age ≤65 years) for both allele (P = 0.0047, OR = 2.52) and genotype (P = 0.0031, OR = 2.92) frequencies. All positive findings remained significant even after correction for multiple comparisons. No significant differences were noted in either the male group or the older age group. No significant differences were found for the other markers (one SLC11A1 marker and one IL8RB marker) either.-
dcterms.abstractConclusion: This study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationBMC infectious diseases, 19 Mar. 2007, v. 7, 19, p. 1-9-
dcterms.isPartOfBMC infectious diseases-
dcterms.issued2007-03-19-
dc.identifier.isiWOS:000245448100001-
dc.identifier.scopus2-s2.0-34147178250-
dc.identifier.pmid17371589-
dc.identifier.rosgroupidr33593-
dc.description.ros2006-2007 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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