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http://hdl.handle.net/10397/35703
| Title: | Rapid analysis of raw solution samples by C18 pipette-tip electrospray ionization mass spectrometry | Authors: | Wang, H So, PK Ng, TT Yao, ZP |
Issue Date: | 24-Sep-2014 | Source: | Analytica chimica acta, 24 Sept. 2014, v. 844, p. 1-7 | Abstract: | A C18 pipette-tip electrospray ionization mass spectrometry technique was developed for rapid analysis of raw solution samples. In this technique, a C18 pipette tip was employed for rapid purification and enrichment of analytes in raw sample solutions. The adsorbed analytes were eluted by solvents supplied by a syringe and a syringe pump, and a high voltage was applied onto the syringe needle to induce electrospray ionization at the pipette tip end for mass spectrometric analysis. This technique is simple, easy to assemble, enables generation of stable and reproducible signals, and can be conveniently used for qualitative and quantitative analysis of raw solution samples. Analysis by the technique only involved simple sample preparation procedures followed by direct mass spectrometric detection, all of which could be completed within minutes, while the analytical performances of the technique, including the limit of detection, limit of quantitation, liner range, accuracy and precision, were comparable to those by conventional methods. | Keywords: | Electrospray ionization mass spectrometry Pipette tips C18 Raw solutions Proteins Ketamine |
Publisher: | Elsevier | Journal: | Analytica chimica acta | ISSN: | 0003-2670 | DOI: | 10.1016/j.aca.2014.07.011 | Rights: | © 2014 Elsevier B.V. All rights reserved. © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The following publication Wang, H., So, P. K., Ng, T. T., & Yao, Z. P. (2014). Rapid analysis of raw solution samples by C18 pipette-tip electrospray ionization mass spectrometry. Analytica Chimica Acta, 844, 1-7 is available at https://doi.org/10.1016/j.aca.2014.07.011. |
| Appears in Collections: | Journal/Magazine Article |
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| Rapid_Analysis_Raw.pdf | Pre-Published version | 1.08 MB | Adobe PDF | View/Open |
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