Please use this identifier to cite or link to this item:
PIRA download icon_1.1View/Download Full Text
Title: Global flash multifocal electroretinogram : early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes
Authors: Lung, JCY
Swann, PG
Wong, DSH
Chan, HHL 
Issue Date: Oct-2012
Source: Documenta ophthalmologica, Oct. 2012, v. 125, no. 2, p. 123-135
Abstract: Purpose To investigate the correlations of the global flash multifocal electroretinogram (MOFO mfERG) with common clinical visual assessments-Humphrey perimetry and Stratus circumpapillary retinal nerve fiber layer (RNFL) thickness measurement in type II diabetic patients. Methods Forty-two diabetic patients participated in the study: Ten were free from diabetic retinopathy (DR), while the remainder suffered from mild to moderate nonproliferative diabetic retinopathy. Fourteen age-matched controls were recruited for comparison. MOFO mfERG measurements were made under high- and low-contrast conditions. Humphrey central 30-2 perimetry and Stratus OCT circumpapillary RNFL thickness measurements were also performed. Correlations between local values of implicit time and amplitude of the mfERG components [direct component (DC) and induced component (IC)], and perimetric sensitivity and RNFL thickness were evaluated by mapping the localized responses for the three subject groups. Results MOFO mfERG was superior to perimetry and RNFL assessments in showing differences between the diabetic groups (with and without DR) and the controls. All the MOFO mfERG amplitudes (except IC amplitude at high contrast) correlated better with perimetry findings (Pearson's r ranged from 0.23 to 0.36, p < 0.01) than did the mfERG implicit time at both high and low contrasts across all subject groups. No consistent correlation was found between the mfERG and RNFL assessments for any group or contrast conditions. The responses of the local MOFO mfERG correlated with local perimetric sensitivity but not with RNFL thickness. Conclusion Early functional changes in the diabetic retina seem to occur before morphological changes in the RNFL.
Keywords: Diabetes mellitus
Diabetic retinopathy
Multifocal electroretinogram
Visual field
Retinal nerve fiber thickness
Retinal functions
Publisher: Springer
Journal: Documenta Ophthalmologica 
ISSN: 0012-4486
DOI: 10.1007/s10633-012-9343-0
Rights: © Springer-Verlag 2012
This is a post-peer-review, pre-copyedit version of an article published in Documenta Ophthalmologica. The final authenticated version is available online at:
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
a0780-n02_1626.pdfPre-Published version1.42 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Final Accepted Manuscript
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

Last Week
Last month
Citations as of May 28, 2023


Citations as of May 28, 2023


Last Week
Last month
Citations as of May 25, 2023


Last Week
Last month
Citations as of Jun 1, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.