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http://hdl.handle.net/10397/34098
| Title: | MicroRNAs involved in anti-tumour immunity | Authors: | Yu, HWH Sze, DMY Cho, WCS |
Issue Date: | 2013 | Source: | International journal of molecular sciences, Mar. 2013, v. 14, no. 3, p. 5587-5607 | Abstract: | MicroRNAs (miRNAs) are a category of small RNAs that constitute a new layer of complexity to gene regulation within the cell, which has provided new perspectives in understanding cancer biology. The deregulation of miRNAs contributes critically to the development and pathophysiology of a number of cancers. miRNAs have been found to participate in cell transformation and multiplication by acting as tumour oncogenes or suppressors; therefore, harnessing miRNAs may provide promising cancer therapeutics. Another major function of miRNAs is their activity as critical regulatory vehicles eliciting important regulatory processes in anti-tumour immunity through their influence on the development, differentiation and activation of various immune cells of both innate and adaptive immunity. This review aims to summarise recent findings focusing on the regulatory mechanisms of the development, differentiation, and proliferative aspects of the major immune populations by a diverse profile of miRNAs and may enrich our current understanding of the involvement of miRNAs in anti-tumour immunity. | Keywords: | Anti-tumour Immunity MicroRNA |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | International journal of molecular sciences | ISSN: | 1661-6596 | EISSN: | 1422-0067 | DOI: | 10.3390/ijms14035587 | Rights: | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). The following publication Yu, H. W. H., Sze, D. M. Y., & Cho, W. C. S. (2013). MicroRNAs involved in anti-tumour immunity. International Journal of Molecular Sciences, 14(3), (Suppl. ), 5587-5607 is available athttps://dx.doi.org/10.3390/ijms14035587 |
| Appears in Collections: | Journal/Magazine Article |
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