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http://hdl.handle.net/10397/28833
Title: | Bond formation of surface-tethered receptor-ligand pairs in relative separation | Authors: | Qian, J Lin, Y Jiang, H Yao, H |
Issue Date: | 2013 | Source: | Applied physics letters, 2013, v. 103, no. 22, 223702, p. 223702-1-223702-5 | Abstract: | We theoretically and numerically investigate the interplay between diffusion of a surface-bound receptor and its reaction with an opposing ligand. Special attention has been paid to the mechanical regulation of bond association by varying the initial gap distance and relative separation speed between the protein-bearing surfaces. Such diffusion-reaction coupling effects can cause the apparent on-rate or reciprocal of the average waiting time for bond formation, to be not constant, but instead a function sensitive to the system parameters that affect the transport of proteins. The results provide a quantitative understanding of how significantly the transport mechanism can affect overall binding behavior of molecular interactions and call for a paradigm shift in modeling receptor-ligand bond association when the protein-bearing surfaces are in relative separation. | Publisher: | American Institute of Physics | Journal: | Applied physics letters | ISSN: | 0003-6951 | EISSN: | 1077-3118 | DOI: | 10.1063/1.4834915 | Rights: | © 2013 AIP Publishing LLC. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in J. Qian et al., Appl. Phys. Lett. 103, 223702 (2013) and may be found at https://dx.doi.org/10.1063/1.4834915 |
Appears in Collections: | Journal/Magazine Article |
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