Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/19672
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dc.contributorDepartment of Rehabilitation Sciencesen_US
dc.creatorBorschmann, Ken_US
dc.creatorPang, MYCen_US
dc.creatorIuliano, Sen_US
dc.creatorChurilov, Len_US
dc.creatorBrodtmann, Aen_US
dc.creatorEkinci, EIen_US
dc.creatorBernhardt, Jen_US
dc.date.accessioned2015-07-13T10:34:05Z-
dc.date.available2015-07-13T10:34:05Z-
dc.identifier.issn1747-4930en_US
dc.identifier.urihttp://hdl.handle.net/10397/19672-
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.rightsThis is the accepted version of the publication Borschmann, Karen, et al. “Changes to Volumetric Bone Mineral Density and Bone Strength after Stroke: A Prospective Study.” International Journal of Stroke, vol. 10, no. 3, Apr. 2015, pp. 396–399. Copyright © 2013 (The Author(s)). DOI: 10.1111/ijs.12228.en_US
dc.rights© 2013 The Authors.en_US
dc.rightsInternational Journal of Stroke © 2013 World Stroke Organizationen_US
dc.subjectBone mineral densityen_US
dc.subjectBone structureen_US
dc.subjectFractureen_US
dc.subjectHR-pQCTen_US
dc.subjectPhysical activityen_US
dc.subjectStrokeen_US
dc.titleChanges to volumetric bone mineral density and bone strength after stroke : a prospective studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage396en_US
dc.identifier.epage399en_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.doi10.1111/ijs.12228en_US
dcterms.abstractStroke survivors experience accelerated bone loss and increased fracture risk, particularly in paretic weight bearing limbs. Understanding how these changes unfold and their relationship to stroke severity and physical activity could help in the development of targeted interventions to prevent or reduce the severity of these outcomes. The primary aim of this study is to investigate the time course and magnitude of changes in volumetric bone mineral density within the first year after stroke, and to examine relationships with physical activity and motor recovery. Design: This is a prospective, observational study of 43 nondiabetic, nonambulant adults with first ever hemispheric stroke. Primary outcome: The primary outcome was the difference in six-month change of total volumetric bone mineral density between paretic and nonparetic distal tibiae, measured at 7% of bone length site using high-resolution peripheral quantitative computed tomography. Secondary outcomes: The secondary outcomes are cortical and trabecular volumetric bone mineral density, cortical thickness, and total and cross-sectional areas of distal tibiae and radii of paretic and nonparetic limbs. Also included are total body and regional bone mineral density derived using dual-energy X-ray absorptiometry, physical activity measured using accelerometry, and motor recovery (Chedoke McMaster Stroke Assessment). Discussion: Measuring the timing and magnitude of changes to volumetric bone mineral density and bone structure from immediately after stroke, and relationships between these changes with physical activity and motor recovery will provide the basis for targeted interventions to reduce fracture risk in stroke survivors.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationInternational journal of stroke, 1 Apr. 2015, v. 10, no. 3, p. 396-399en_US
dcterms.isPartOfInternational Journal of Strokeen_US
dcterms.issued2015-04-01-
dc.identifier.scopus2-s2.0-84924859249-
dc.identifier.rosgroupid2014000864-
dc.description.ros2014-2015 > Academic research: refereed > Publication in refereed journalen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera0590-n02, a0590-n14-
dc.identifier.SubFormID326, 338-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
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