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Title: Segmentation of dynamic PET images using cluster analysis
Authors: Wong, KP
Feng, DD
Meikle, SR
Fulham, MJ
Issue Date: 2001
Source: 2000 IEEE Nuclear Science Symposium conference record : October 15-20, 2000, Lyon, France, v. 3, p. 18/126 - 18/130
Abstract: Quantitative PET studies can provide in-vivo measurements of dynamic physiological and biochemical processes in humans. A limitation of PET is its inability to provide precise anatomic localisation due to relatively poor spatial resolution when compared to MR imaging. Manual placement of regions of interest (ROIs) is commonly used in the clinical and research settings in analysis of PET datasets. However, this approach is operator dependent and time-consuming. Semi- or fully-automated ROI delineation (or segmentation) methods offer advantages by reducing operator error and subjectivity and thereby improving reproducibility. In this work, we describe an approach to automatically segment dynamic PET images using cluster analysis, and we validate our approach with a simulated phantom study and assess its performance in segmentation of dynamic lung data. Our preliminary results suggest that cluster analysis can be used to automatically segment tissues in dynamic PET studies and has the potential to replace manual ROI delineation.
Keywords: Image segmentation
Medical image processing
Positron emission tomography
Publisher: IEEE
ISBN: 0-7803-6503-8
DOI: 10.1109/NSSMIC.2000.949251
Rights: © 2001 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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