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Title: Evaluation of hepatocellular carcinoma with dynamic ¹¹C-acetate PET : a dual-modeling method
Authors: Chen, S
Feng, DD
Issue Date: Jun-2008
Source: IEEE transactions on nuclear science, June 2008, v. 55, no. 3, p. 999-1007
Abstract: Quantification of the ¹¹C-acetate liver studies with dynamic positron emission tomography (PET) could significantly improve the evaluation of hepatocellular carcinoma (HCC), where both time-activity curves (TACs) of the hepatic artery (HA) and portal vein (PV) (the dual hepatic blood supply) are required. However, directly measuring them by the blood sampling or cannulation procedure is very invasive. In addition, it is very hard to differentiate the PV from the surrounding liver tissue on PET images by the currently developed indirect methods. To noninvasively and efficiently access the TAC of PV, we investigated the possibility of modeling the dual hepatic blood supply and presented two hepatic dual-input (DI) models. Combining the established ¹¹C-acetate liver model with two different DI models, we obtained two dual-models with six/seven parameters to fit the dynamic PET measurements. The fitting results were compared with those of the ¹¹C-acetate liver model using image-derived dual hepatic inputs (the "Golden standard") by statistical study. The adequacy of the two dual-models was estimated by Akaike Information Criteria (AIC) and Schwarz Criteria (SC). It was revealed that the proposed modeling technique could successfully account for the hepatic dual blood supply and the six-parameter (6-P) dual-model is more suitable for quantification of ¹¹C-acetate liver studies.
Keywords: Dual-model
Hepatic dual-input (DI) model
Hepatocellular carcinoma (HCC)
Parameter estimation
Positron emission tomography (PET)
Publisher: Institute of Electrical and Electronics Engineers
Journal: IEEE transactions on nuclear science 
ISSN: 0018-9499
EISSN: 1558-1578
DOI: 10.1109/TNS.2008.924075
Rights: © 2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
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