Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/117958
| DC Field | Value | Language |
|---|---|---|
| dc.contributor | Department of Applied Biology and Chemical Technology | - |
| dc.contributor | Mainland Development Office | - |
| dc.creator | Zhu, C | - |
| dc.creator | Xu, Y | - |
| dc.creator | Hao, Z | - |
| dc.creator | Zhuang, Y | - |
| dc.creator | Xu, R | - |
| dc.creator | Pan, Y | - |
| dc.creator | Shi, J | - |
| dc.creator | Li, Y | - |
| dc.creator | Jiang, Y | - |
| dc.creator | Wang, T | - |
| dc.creator | Yang, YR | - |
| dc.creator | Liu, H | - |
| dc.creator | Han, D | - |
| dc.creator | Dong, Y | - |
| dc.creator | He, C | - |
| dc.creator | Liu, D | - |
| dc.date.accessioned | 2026-03-09T06:46:27Z | - |
| dc.date.available | 2026-03-09T06:46:27Z | - |
| dc.identifier.issn | 1433-7851 | - |
| dc.identifier.uri | http://hdl.handle.net/10397/117958 | - |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley-VCH Verlag GmbH & Co. KGaA | en_US |
| dc.subject | 5-Methyl cytosine | en_US |
| dc.subject | Epigenetics | en_US |
| dc.subject | Long single-stranded DNA | en_US |
| dc.subject | Single-base resolution | en_US |
| dc.subject | Site-specific modifications | en_US |
| dc.title | Long single-stranded DNA with site-specific modifications to enable single-base-resolution epigenetics | en_US |
| dc.type | Journal/Magazine Article | en_US |
| dc.identifier.volume | 65 | - |
| dc.identifier.issue | 3 | - |
| dc.identifier.doi | 10.1002/anie.202513078 | - |
| dcterms.abstract | We report a method for synthesizing site-specifically modified long single-stranded DNA (ssDNA) with high purity and fidelity. With the successful synthesis of long ssDNA carrying different 5-methylcytosine (5mC) patterns, single-base-resolution analysis of 5mC epigenetic dynamics at specific genomic loci were enabled in mammalian cells. The results revealed that the density of 5mC sites synergistically correlated with their maintenance. This study opens new avenues for precise epigenetic manipulation and therapeutic applications. | - |
| dcterms.accessRights | embargoed access | en_US |
| dcterms.bibliographicCitation | Angewandte chemie international edition, 16 Jan. 2026, v. 65, no. 3, e13078 | - |
| dcterms.isPartOf | Angewandte chemie international edition | - |
| dcterms.issued | 2026-01-16 | - |
| dc.identifier.scopus | 2-s2.0-105022653959 | - |
| dc.identifier.eissn | 1521-3773 | - |
| dc.identifier.artn | e13078 | - |
| dc.description.validate | 202603 bcjz | - |
| dc.description.oa | Not applicable | en_US |
| dc.identifier.SubFormID | G001144/2026-01 | en_US |
| dc.description.fundingSource | Others | en_US |
| dc.description.fundingText | The authors would like to thank the National Basic Research Plan of China (2023YFA0915201, 2024YFA1308500), Beijing Natural Science Foundation (JQ24007), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB0960000), National Natural Science Foundation of China (22477122, 32270627), and Open Project of State Key Laboratory of Supramolecular Structure and Materials (sklssm202506). Some figures were created with Biorender.com. | en_US |
| dc.description.pubStatus | Published | en_US |
| dc.date.embargo | 2027-01-16 | en_US |
| dc.description.oaCategory | Green (AAM) | en_US |
| Appears in Collections: | Journal/Magazine Article | |
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