Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/11724
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dc.contributorSchool of Optometry-
dc.creatorHo, WC-
dc.creatorKee, CS-
dc.creatorChan, HHL-
dc.date.accessioned2015-07-14T01:28:43Z-
dc.date.available2015-07-14T01:28:43Z-
dc.identifier.issn0146-0404-
dc.identifier.urihttp://hdl.handle.net/10397/11724-
dc.language.isoenen_US
dc.publisherAssociation for Research in Vision and Ophthalmologyen_US
dc.rightsPosted with permission of the publisher.en_US
dc.rightsCopyright 2012 The Association for Research in Vision and Ophthalmology, Inc.en_US
dc.titleMyopia progression in children is linked with reduced foveal mfERG responseen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage5320-
dc.identifier.epage5325-
dc.identifier.volume53-
dc.identifier.issue9-
dc.identifier.doi10.1167/iovs.12-10185-
dcterms.abstractPurpose. To study the changes in retinal electrophysiology in children during myopia progression during a 1-year period. Methods. Twenty-six children aged from 9 to 13 years were recruited for the global flash multifocal electroretinogram (mfERG) measured at 49% and 96% contrast, in two visits 1 year apart. The amplitudes and implicit times of both direct component (DC) and induced component (IC) measured at these two visits were analyzed and compared. Pearson's correlation was used to study the association between the changes of mfERG response and myopia progression during the test period. Results. Myopia increased by -0.48 ± 0.32 diopter (D) (P < 0.001) during the year, with 24 of 26 children becoming more myopic (range = 0.00 to ~ -1.38 D); axial length increased by 0.25 ± 0.11 mm (P < 0.001) during the year. The increased myopia was highly correlated with increase in axial length (r = -0.70; P < 0.001). The central DC and IC amplitudes at 49% contrast reduced significantly as myopia progressed and the paracentral implicit times of these two components were reduced considerably. However, the high-contrast responses were virtually unaffected. Conclusions. Our findings suggested that the inner retinal functions in the central retina, with some involvement of the paracentral region, were decreased as myopia progressed in children.-
dcterms.accessRightsopen access-
dcterms.bibliographicCitationInvestigative ophthalmology and visual science, 2012, v. 53, no. 9, p. 5320-5325-
dcterms.isPartOfInvestigative ophthalmology and visual science-
dcterms.issued2012-
dc.identifier.isiWOS:000308695400029-
dc.identifier.scopus2-s2.0-84867842000-
dc.identifier.pmid22761262-
dc.identifier.eissn1552-5783-
dc.identifier.rosgroupidr62553-
dc.description.ros2012-2013 > Academic research: refereed > Publication in refereed journal-
dc.description.oaVersion of Record-
dc.identifier.FolderNumbera0780-n09-
dc.identifier.SubFormID1633-
dc.description.fundingSourceOthers-
dc.description.fundingTextJ-BB7P, J-BB76-
dc.description.pubStatusPublished-
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