Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/115005
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Title: Hybrid-RViT: hybridizing resnet-50 and vision transformer for enhanced alzheimer's disease detection
Authors: Yan, HJ
Mubonanyikuzo, V
Komolafe, TE
Zhou, L
Wu, T
Wang, NZ 
Issue Date: 2025
Source: PLoS one, 2025, v. 20, no. 2, e0318998
Abstract: Alzheimer's disease (AD) is a leading cause of disability worldwide. Early detection is critical for preventing progression and formulating effective treatment plans. This study aims to develop a novel deep learning (DL) model, Hybrid-RViT, to enhance the detection of AD. The proposed Hybrid-RViT model integrates the pre-trained convolutional neural network (ResNet-50) with the Vision Transformer (ViT) to classify brain MRI images across different stages of AD. The ResNet-50 adopted for transfer learning, facilitates inductive bias and feature extraction. Concurrently, ViT processes sequences of image patches to capture long-distance relationships via a self-attention mechanism, thereby functioning as a joint local-global feature extractor. The Hybrid-RViT model achieved a training accuracy of 97% and a testing accuracy of 95%, outperforming previous models. This demonstrates its potential efficacy in accurately identifying and classifying AD stages from brain MRI data. The Hybrid-RViT model, combining ResNet-50 and ViT, shows superior performance in AD detection, highlighting its potential as a valuable tool for medical professionals in interpreting and analyzing brain MRI images. This model could significantly improve early diagnosis and intervention strategies for AD.
Publisher: Public Library of Science
Journal: PLoS one 
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0318998
Rights: © 2025 Yan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The following publication Yan H, Mubonanyikuzo V, Komolafe TE, Zhou L, Wu T, Wang N (2025) Hybrid-RViT: Hybridizing ResNet-50 and Vision Transformer for Enhanced Alzheimer’s disease detection. PLoS ONE 20(2): e0318998 is available at https://dx.doi.org/10.1371/journal.pone.0318998.
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