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dc.contributorDepartment of Health Technology and Informaticsen_US
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dc.date.accessioned2025-07-15T08:44:21Z-
dc.date.available2025-07-15T08:44:21Z-
dc.identifier.issn1552-5260en_US
dc.identifier.urihttp://hdl.handle.net/10397/114203-
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights© 2024 The Author(s). Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.en_US
dc.rightsThe following publication The Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimer's Dement. 2024; 20: 5973-5995 is available at https://doi.org/10.1002/alz.14115.en_US
dc.subjectAll-cause dementiaen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectCross-ancestryen_US
dc.subjectGenome-wide association study (GWAS)en_US
dc.subjectGWAS meta-analysisen_US
dc.subjectVascular dementiaen_US
dc.titleA genome-wide association meta-analysis of all-cause and vascular dementiaen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage5973en_US
dc.identifier.epage5995en_US
dc.identifier.volume20en_US
dc.identifier.issue9en_US
dc.identifier.doi10.1002/alz.14115en_US
dcterms.abstractINTRODUCTION: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.en_US
dcterms.abstractMETHODS: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors.en_US
dcterms.abstractRESULTS: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3).en_US
dcterms.abstractDISCUSSION: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationAlzheimer's and dementia: the journal of the Alzheimer Association, Sept 2024, v. 20, no. 9, p. 5973-5995en_US
dcterms.isPartOfAlzheimer's and dementia: the journal of the Alzheimer Associationen_US
dcterms.issued2024-09-
dc.identifier.scopus2-s2.0-85199503848-
dc.identifier.eissn1552-5279en_US
dc.description.validate202507 bcchen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera3893b-
dc.identifier.SubFormID51584-
dc.description.fundingSourceSelf-fundeden_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryCCen_US
Appears in Collections:Journal/Magazine Article
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