Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/112649
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorSun, Cen_US
dc.creatorLiu, Sen_US
dc.creatorLau, JWen_US
dc.creatorYang, Hen_US
dc.creatorChen, Yen_US
dc.creatorXing, Ben_US
dc.date.accessioned2025-04-24T02:54:00Z-
dc.date.available2025-04-24T02:54:00Z-
dc.identifier.issn1433-7851en_US
dc.identifier.urihttp://hdl.handle.net/10397/112649-
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaAen_US
dc.subjectBioorthogonal click chemistryen_US
dc.subjectImmunomodulationen_US
dc.subjectPROTACsen_US
dc.subjectTarget protein degradationen_US
dc.subjectTumor microenvironment-responsiveen_US
dc.titleEnzyme-activated orthogonal proteolysis chimeras for tumor microenvironment-responsive immunomodulationen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.doi10.1002/anie.202423057en_US
dcterms.abstractWe present a novel tumor microenvironment (TME)-responsive enzyme-activated clickable PROTACs, enabling the in situ formation of heterobifunctional degraders to disrupt epigenetic BRD4 proteins in the tumor only. Such clickable-PROTACs exhibit promising selectivity and superior penetration in tumors, effectively downregulating PD−L1 expression both in vitro and in vivo, offering potential for immunotherapy against tumor growth.en_US
dcterms.abstractGraphical abstract: [Figure not available: see fulltext.]en_US
dcterms.accessRightsembargoed accessen_US
dcterms.bibliographicCitationAngewandte chemie international edition, First published: 11 February 2025, Early View, e202423057, https://doi.org/10.1002/anie.202423057en_US
dcterms.isPartOfAngewandte chemie international editionen_US
dcterms.issued2025-
dc.identifier.eissn1521-3773en_US
dc.identifier.artne202423057en_US
dc.description.validate202504 bcchen_US
dc.description.oaNot applicableen_US
dc.identifier.FolderNumbera3553-
dc.identifier.SubFormID50341-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextthe Global JC STEM Professorship; MOE Tier 1 RG4/22, RG12/24, MoE AcRF Tier 1 Theme RT7/22en_US
dc.description.pubStatusEarly releaseen_US
dc.date.embargo0000-00-00 (to be updated)en_US
dc.description.oaCategoryGreen (AAM)en_US
dc.relation.rdatahttps://www.polyu.edu.hk/abct/people/academic-staff/prof-xing-bengang/?sc_lang=enen_US
Appears in Collections:Journal/Magazine Article
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Embargo End Date 0000-00-00 (to be updated)
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