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Title: The co-occurrence of depression and dissociation : the relevance of childhood trauma
Authors: Fung, HW 
Ho, WKG 
Ki, Lam, SK
Chun, Chau, AK
Şar, V
Ross, CA
Lee, K
Chien, WT
Wong, JYH
Issue Date: Mar-2025
Source: Journal of psychiatric research, Mar. 2025, v. 183, p. 157-163
Abstract: Recent studies showed that dissociation may be common and persistent in people with depression. Dissociation also predicts subsequent depressive symptoms. Both conditions have been linked with trauma exposure. Yet, little is known about the co-occurrence of depression and dissociation. This multi-sample study investigated the co-occurrence of depressive and dissociative symptoms and its relationship with different types of childhood trauma. We analyzed available data from five samples of Chinese adults (N = 2737 in total). Participants completed the same set of measures of depressive and dissociative symptoms and childhood betrayal and non-betrayal trauma. Across samples, between 22.0% and 50.6% of participants with depression exhibited co-occurring dissociation; the majority of participants with dissociation (67.0%–90.2%) presented with depression too. One-way ANCOVA showed that participants who presented with both depression and dissociation reported a statistically significantly higher number of childhood betrayal and non-betrayal trauma types compared to those who had only one or none of these conditions. Exploratory mediation analysis also revealed that dissociative symptoms partly mediated the relationship between childhood trauma and depressive symptoms, regardless of the type of trauma. Findings suggest that the co-occurrence of depressive and dissociative symptoms is associated with childhood trauma. Individuals who report depressive symptoms or seek treatments for a depressive disorder should be screened for dissociation. Further studies on the reliability, validity, clinical features, and intervention needs of the possible dissociative subtype of depression are required.
Keywords: Affective disorders
Betrayal trauma
Childhood trauma
Comorbidity
Dissociative depression
Public mental health
Publisher: Elsevier Ltd
Journal: Journal of psychiatric research 
ISSN: 0022-3956
EISSN: 1879-1379
DOI: 10.1016/j.jpsychires.2025.02.026
Rights: © 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
The following publication Fung, H. W., Ho, G. W. K., Lam, S. K. K., Chau, A. K. C., Şar, V., Ross, C. A., ... & Wong, J. Y. H. (2025). The co-occurrence of depression and dissociation: The relevance of childhood trauma. Journal of Psychiatric Research, 183, 157-163 is available at https://doi.org/10.1016/j.jpsychires.2025.02.026.
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