Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/110529
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dc.contributorDepartment of Biomedical Engineering-
dc.creatorChen, H-
dc.creatorYin, W-
dc.creatorYao, K-
dc.creatorLiang, J-
dc.creatorCai, J-
dc.creatorSui, X-
dc.creatorZhao, X-
dc.creatorZhang, J-
dc.creatorXiao, J-
dc.creatorLi, R-
dc.creatorLiu, Q-
dc.creatorYao, J-
dc.creatorYou, G-
dc.creatorLiu, Y-
dc.creatorJiang, C-
dc.creatorQiu, X-
dc.creatorWang, T-
dc.creatorYou, Q-
dc.creatorZhang, Y-
dc.creatorYang, M-
dc.creatorZheng, J-
dc.creatorDai, Z-
dc.creatorYang, Y-
dc.date.accessioned2024-12-17T00:43:27Z-
dc.date.available2024-12-17T00:43:27Z-
dc.identifier.urihttp://hdl.handle.net/10397/110529-
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaAen_US
dc.rights© 2024 The Author(s). Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rightsThe following publication H. Chen, W. Yin, K. Yao, J. Liang, J. Cai, X. Sui, X. Zhao, J. Zhang, J. Xiao, R. Li, Q. Liu, J. Yao, G. You, Y. Liu, C. Jiang, X. Qiu, T. Wang, Q. You, Y. Zhang, M. Yang, J. Zheng, Z. Dai, Y. Yang, Mesenchymal Stem Cell Membrane-Camouflaged Liposomes for Biomimetic Delivery of Cyclosporine A for Hepatic Ischemia-Reperfusion Injury Prevention. Adv. Sci. 2024, 11, 2404171 is available at https://doi.org/10.1002/advs.202404171.en_US
dc.subjectBiomimetic deliveryen_US
dc.subjectCyclosporine Aen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectMesenchymal stem cellen_US
dc.titleMesenchymal stem cell membrane-camouflaged liposomes for biomimetic delivery of cyclosporine a for hepatic ischemia-reperfusion injury preventionen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume11-
dc.identifier.issue32-
dc.identifier.doi10.1002/advs.202404171-
dcterms.abstractHepatic ischemia-reperfusion injury (HIRI) is a prevalent issue during liver resection and transplantation, with currently no cure or FDA-approved therapy. A promising drug, Cyclosporin A (CsA), ameliorates HIRI by maintaining mitochondrial homeostasis but has systemic side effects due to its low bioavailability and high dosage requirements. This study introduces a biomimetic CsA delivery system that directly targets hepatic lesions using mesenchymal stem cell (MSC) membrane-camouflaged liposomes. These hybrid nanovesicles (NVs), leveraging MSC-derived proteins, demonstrate efficient inflammatory chemotaxis, transendothelial migration, and drug-loading capacity. In a HIRI mouse model, the biomimetic NVs accumulated at liver injury sites entered hepatocytes, and significantly reduced liver damage and restore function using only one-tenth of the CsA dose typically required. Proteomic analysis verifies the protection mechanism, which includes reactive oxygen species inhibition, preservation of mitochondrial integrity, and reduced cellular apoptosis, suggesting potential for this biomimetic strategy in HIRI intervention.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationAdvanced science, 27 Aug. 2024, v. 11, no. 32, 2404171-
dcterms.isPartOfAdvanced science-
dcterms.issued2024-08-27-
dc.identifier.scopus2-s2.0-85196378677-
dc.identifier.eissn2198-3844-
dc.identifier.artn2404171-
dc.description.validate202412 bcch-
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumberOA_Scopus/WOSen_US
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextNational Key Research and Development Program of China; National Natural Science Foundation of China; Hong Kong Polytechnic University Postdoctoral Fellowship Fund; Science and Technology Program of Guangdong Province; Natural Science Foundation of Guangdong Province; Science and Technology Program of Guangzhou; Major talent project cultivation plan project of 3rd A?liated Hospital of SYSU; China Postdoctoral Science Foundationen_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryCCen_US
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