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| Title: | Effects of nicotinamide mononucleotide on glucose and lipid metabolism in adults : a systematic review and meta-analysis of randomised controlled trials | Authors: | Chen, F Zhou, D Kong, APS Yim, NT Dai, S Chen, YN Hui, LL |
Issue Date: | Dec-2025 | Source: | Current diabetes reports, Dec. 2025, v. 25, no. 1, 4 | Abstract: | Purpose of Review: Supplementation of nicotinamide mononucleotides (NMN) has been claimed to improve metabolic function. We reviewed human randomised controlled trials (RCTs) of NMN to evaluate its effect on markers of glucose and lipid metabolism. Recent Findings: Eight RCTs on NMN (dosage ranged 250–2000 mg/d for a duration of 14 days to 12 weeks) involving a total of 342 middle-age/older adults (49% females, mainly non-diabetic) reporting at least one outcome on glucose control or lipid profile published in 2021–2023 were reviewed. The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile. Summary: Based on the small number of RCTs involving mainly relatively healthy adults, short-term supplementation of NMN of 250-2000 mg/d did not show significantly positive impacts on glucose control and lipid profile. |
Keywords: | Glucose control Lipid profile NAD Nicotinamide mononucleotide Supplementation |
Publisher: | Springer Healthcare | Journal: | Current diabetes reports | ISSN: | 1534-4827 | EISSN: | 1539-0829 | DOI: | 10.1007/s11892-024-01557-z | Rights: | © The Author(s) 2024 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The following publication Chen, F., Zhou, D., Kong, A.PS. et al. Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Curr Diab Rep 25, 4 (2025) is available at https://doi.org/10.1007/s11892-024-01557-z. |
| Appears in Collections: | Journal/Magazine Article |
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|---|---|---|---|---|
| s11892-024-01557-z.pdf | 2.23 MB | Adobe PDF | View/Open |
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