Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/108920
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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorShi, Jen_US
dc.creatorZhu, Zen_US
dc.creatorYang, Zen_US
dc.creatorLin, Yen_US
dc.creatorYu, Ten_US
dc.creatorZhong, Men_US
dc.creatorLo, TWBen_US
dc.creatorChen, Xen_US
dc.creatorLuan, Ten_US
dc.date.accessioned2024-09-10T06:06:38Z-
dc.date.available2024-09-10T06:06:38Z-
dc.identifier.issn1523-7060en_US
dc.identifier.urihttp://hdl.handle.net/10397/108920-
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2024 American Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.4c00006.en_US
dc.titleIn situ activation of azaarenes and terminal alkynes to construct bridged polycyclic compounds containing isoquinolinonesen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage2002en_US
dc.identifier.epage2006en_US
dc.identifier.volume26en_US
dc.identifier.issue10en_US
dc.identifier.doi10.1021/acs.orglett.4c00006en_US
dcterms.abstractA copper-catalyzed [4+2] cyclization reaction of isoquinolines and alkynes is developed for the one-step construction of isoquinolinone derivatives with multisubstituted bridging rings. The unique feature of this three-component tandem cyclization reaction is the functionalization of the C1, N2, C3, and C4 positions of 3-haloisoquinolines via the construction of new C–N, C═O, and C–C bonds. This dearomatization strategy for the synthesis of structurally complex isoquinolinone-bridged cyclic compounds offers good chemoselectivity, broad functional group compatibility, greenness, and high step economy.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationOrganic letters, 15 Mar. 2024, v. 26, no. 10, p. 2002-2006en_US
dcterms.isPartOfOrganic lettersen_US
dcterms.issued2024-03-15-
dc.identifier.scopus2-s2.0-85186199509-
dc.identifier.pmid38394378-
dc.identifier.eissn1523-7052en_US
dc.description.validate202409 bcchen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumbera3170-
dc.identifier.SubFormID49723-
dc.description.fundingSourceRGCen_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryGreen (AAM)en_US
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