Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107483
DC Field | Value | Language |
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dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.contributor | School of Optometry | - |
dc.contributor | Research Centre for SHARP Vision | - |
dc.creator | Mansoor, H | - |
dc.creator | Lee, IXY | - |
dc.creator | Lin, MTY | - |
dc.creator | Ang, HP | - |
dc.creator | Xue, YC | - |
dc.creator | Krishaa, L | - |
dc.creator | Patil, M | - |
dc.creator | Koh, SK | - |
dc.creator | Tan, HC | - |
dc.creator | Zhou, L | - |
dc.creator | Liu, YC | - |
dc.date.accessioned | 2024-06-27T01:33:44Z | - |
dc.date.available | 2024-06-27T01:33:44Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/107483 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | © The Author(s) 2024 | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.rights | The following publication Mansoor, H., Lee, I.X.Y., Lin, M.TY. et al. Topical and oral peroxisome proliferator-activated receptor-α agonist ameliorates diabetic corneal neuropathy. Sci Rep 14, 13435 (2024) is available at https://doi.org/10.1038/s41598-024-64451-4. | en_US |
dc.title | Topical and oral peroxisome proliferator-activated receptor-α agonist ameliorates diabetic corneal neuropathy | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 14 | - |
dc.identifier.doi | 10.1038/s41598-024-64451-4 | - |
dcterms.abstract | Diabetic corneal neuropathy (DCN) is a common diabetic ocular complication with limited treatment options. In this study, we investigated the effects of topical and oral fenofibrate, a peroxisome proliferator-activated receptor-α agonist, on the amelioration of DCN using diabetic mice (n = 120). Ocular surface assessments, corneal nerve and cell imaging analysis, tear proteomics and its associated biological pathways, immuno-histochemistry and western blot on PPARα expression, were studied before and 12 weeks after treatment. At 12 weeks, PPARα expression markedly restored after topical and oral fenofibrate. Topical fenofibrate significantly improved corneal nerve fibre density (CNFD) and tortuosity coefficient. Likewise, oral fenofibrate significantly improved CNFD. Both topical and oral forms significantly improved corneal sensitivity. Additionally, topical and oral fenofibrate significantly alleviated diabetic keratopathy, with fenofibrate eye drops demonstrating earlier therapeutic effects. Both topical and oral fenofibrate significantly increased corneal β-III tubulin expression. Topical fenofibrate reduced neuroinflammation by significantly increasing the levels of nerve growth factor and substance P. It also significantly increased β-III-tubulin and reduced CDC42 mRNA expression in trigeminal ganglions. Proteomic analysis showed that neurotrophin signalling and anti-inflammation reactions were significantly up-regulated after fenofibrate treatment, whether applied topically or orally. This study concluded that both topical and oral fenofibrate ameliorate DCN, while topical fenofibrate significantly reduces neuroinflammation. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 2024, v. 14, 13435 | - |
dcterms.isPartOf | Scientific reports | - |
dcterms.issued | 2024 | - |
dc.identifier.scopus | 2-s2.0-85195888315 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.artn | 13435 | - |
dc.description.validate | 202406 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a2889 | en_US |
dc.identifier.SubFormID | 48660 | en_US |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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48660_s41598-024-64451-4.pdf | 4.46 MB | Adobe PDF | View/Open |
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