Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107469
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | - |
dc.creator | Zhang, S | - |
dc.creator | Zhu, Z | - |
dc.creator | Yuan, Y | - |
dc.creator | Chen, Y | - |
dc.creator | Bulloch, G | - |
dc.creator | Huang, W | - |
dc.creator | He, M | - |
dc.creator | Wang, W | - |
dc.date.accessioned | 2024-06-25T04:31:11Z | - |
dc.date.available | 2024-06-25T04:31:11Z | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.uri | http://hdl.handle.net/10397/107469 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc. | en_US |
dc.title | Association of central obesity with retinal neurodegeneration : cross-sectional and longitudinal evidence from two countries | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 2199 | - |
dc.identifier.epage | 2208 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 8 | - |
dc.identifier.doi | 10.1002/oby.23807 | - |
dcterms.abstract | Objective: This study aimed to evaluate the association of central obesity with retinal neurodegeneration. | - |
dcterms.abstract | Methods: Databases from the UK Biobank study and the Chinese Ocular Imaging Project (COIP) were included for cross-sectional and longitudinal analyses, respectively. Retinal ganglion cell-inner plexiform layer thickness (GCIPLT) measured by optical coherence tomography (OCT) was used as a retinal indicator of neurodegeneration. All subjects were divided into six obesity phenotypes according to BMI (normal, overweight, obesity) and waist to hip ratio (WHR; normal, high). Multivariable linear regression models were fitted to investigate the association of obesity phenotypes with GCIPLT. | - |
dcterms.abstract | Results: A total of 22,827 and 2082 individuals from UK Biobank (mean age: 55.06 [SD 8.27] years, women: 53.2%) and COIP (mean age: 63.02 [SD 8.35 years], women: 61.9%) were included, respectively. Cross-sectional analysis showed GCIPLT was significantly thinner in normal BMI/high WHR individuals compared with normal BMI/normal WHR individuals (β = −0.33 μm, 95% CI = −0.61, −0.04, p = 0.045). But thinner GCIPLT was not observed in individuals with obesity/normal WHR. After 2-year follow-up in COIP, normal BMI/high WHR was associated with accelerated GCIPLT thinning (β = −0.28 μm/y, 95% CI = −0.45, −0.10, p = 0.02), whereas obesity/normal WHR was not. | - |
dcterms.abstract | Conclusions: Even with normal weight, central obesity was associated with accelerated GCIPLT thinning cross-sectionally and longitudinally. | - |
dcterms.accessRights | embargoed access | en_US |
dcterms.bibliographicCitation | Obesity, Aug. 2023, v. 31, no. 8, p. 2199-2208 | - |
dcterms.isPartOf | Obesity | - |
dcterms.issued | 2023-08 | - |
dc.identifier.scopus | 2-s2.0-85164589780 | - |
dc.identifier.pmid | 37415077 | - |
dc.identifier.eissn | 1930-739X | - |
dc.description.validate | 202406 bcch | - |
dc.identifier.FolderNumber | a2877b | en_US |
dc.identifier.SubFormID | 48636 | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; Guangzhou Science & Technology Plan of Guangdong Pearl River Talents Program; Fundamental Research Funds of the State Key Laboratory of Ophthalmology | en_US |
dc.description.pubStatus | Published | en_US |
dc.date.embargo | 2024-08-31 | en_US |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
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