Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107468
DC Field | Value | Language |
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dc.contributor | School of Optometry | - |
dc.creator | Liu, J | - |
dc.creator | Roccati, E | - |
dc.creator | Chen, Y | - |
dc.creator | Zhu, Z | - |
dc.creator | Wang, W | - |
dc.creator | He, M | - |
dc.creator | Shang, X | - |
dc.date.accessioned | 2024-06-25T04:31:10Z | - |
dc.date.available | 2024-06-25T04:31:10Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/107468 | - |
dc.language.iso | en | en_US |
dc.publisher | IOS Press | en_US |
dc.rights | © 2024– The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Liu, J., Roccati, E., Chen, Y., Zhu, Z., Wang, W., He, M., & Shang, X. (2024). Seasonal Variations in Vitamin D Levels and the Incident Dementia Among Older Adults Aged ≥60 Years in the UK Biobank 1. Journal of Alzheimer's Disease Reports, 8, 411-422 is available at https://doi.org/10.3233/ADR-230077. | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Dementia | en_US |
dc.subject | Moderation analysis | en_US |
dc.subject | Season | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Seasonal variations in vitamin D levels and the incident dementia among older adults aged ≥60 years in the UK Biobank | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 411 | - |
dc.identifier.epage | 422 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.3233/ADR-230077 | - |
dcterms.abstract | Background: Limited knowledge exists regarding the association between dementia incidence and vitamin D insufficiency/deficiency across seasons. | - |
dcterms.abstract | Objective: This study aimed to evaluate the impact of seasonal serum vitamin D (25(OH)D) levels on dementia and its subtypes, considering potential modifiers. | - |
dcterms.abstract | Methods: We analyzed 193,003 individuals aged 60–73 at baseline (2006–2010) from the UK Biobank cohort, with follow-up until 2018. 25(OH)D were measured at baseline, and incident dementia cases were identified through hospital records, death certificates, and self-reports. | - |
dcterms.abstract | Results: Out of 1,874 documented all-cause dementia cases, the median follow-up duration was 8.9 years. Linear and nonlinear associations between 25(OH)D and dementia incidence across seasons were observed. In multivariable-adjusted analysis, 25(OH)D deficiency was associated with a 1.5-fold (95% CIs: 1.2–2.0), 2.2-fold (1.5–3.0), 2.0-fold (1.5–2.7), and 1.7-fold (1.3–2.3) increased incidence of all-cause dementia in spring, summer, autumn, and winter, respectively. Adjusting for seasonal variations, 25(OH)D insufficiency and deficiency were associated with a 1.3-fold (1.1–1.4) and 1.8-fold (1.6–2.2) increased dementia incidence, respectively. This association remained significant across subgroups, including baseline age, gender, and education levels. Furthermore, 25(OH)D deficiency was associated with a 1.4-fold (1.1–1.8) and 1.5-fold (1.1–2.0) higher incidence of Alzheimer’s disease and vascular dementia, respectively. These associations remained significant across all subgroups. | - |
dcterms.abstract | Conclusions: 25(OH)D deficiency is associated with an increased incidence of dementia and its subtypes throughout the year. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of Alzheimer's disease reports, 2024, v. 8, no. 1, p. 411-422 | - |
dcterms.isPartOf | Journal of Alzheimer's disease reports | - |
dcterms.issued | 2024 | - |
dc.identifier.scopus | 2-s2.0-85188155200 | - |
dc.identifier.eissn | 2542-4823 | - |
dc.description.validate | 202406 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a2877b | en_US |
dc.identifier.SubFormID | 48631 | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Fundamental Research Funds of the State Key Laboratory of Ophthalmology; Project of Investigation on Health Status of Employees in Financial Indus- try in Guangzhou, China; Science and Technology Program of Guangzhou, China; University of Melbourne at Research Accel- erator Program; CERA Foundation; Operational Infrastructure Support from the Victorian State Government.; Australian Government | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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adr-8-adr230077.pdf | 967.59 kB | Adobe PDF | View/Open |
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