Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107465
DC Field | Value | Language |
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dc.contributor | School of Optometry | - |
dc.contributor | Research Centre for SHARP Vision | - |
dc.creator | Xuan, M | en_US |
dc.creator | Wang, W | en_US |
dc.creator | Bulloch, G | en_US |
dc.creator | Zhang, J | en_US |
dc.creator | Ha, J | en_US |
dc.creator | Wang, Q | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Lin, X | en_US |
dc.creator | He, M | en_US |
dc.date.accessioned | 2024-06-25T04:31:09Z | - |
dc.date.available | 2024-06-25T04:31:09Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/107465 | - |
dc.language.iso | en | en_US |
dc.publisher | Association for Research in Vision and Ophthalmology | en_US |
dc.rights | Copyright 2024 The Authors | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Meng Xuan, Wei Wang, Gabriella Bulloch, Jian Zhang, Jason Ha, Qilin Wang, Juanjuan Wang, Xingyan Lin, Mingguang He; Impact of Acute Ocular Hypertension on Retinal Ganglion Cell Loss in Mice. Trans. Vis. Sci. Tech. 2024;13(3):17 is available at https://doi.org/10.1167/tvst.13.3.17. | en_US |
dc.subject | Acute ocular hypertension | en_US |
dc.subject | Duration | en_US |
dc.subject | Intraocular pressure | en_US |
dc.subject | Retinal ganglion cell | en_US |
dc.subject | Yellow fluorescent protein | en_US |
dc.title | Impact of acute ocular hypertension on retinal ganglion cell loss in mice | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.1167/tvst.13.3.17 | en_US |
dcterms.abstract | Purpose: To assess the correlation between intraocular pressure (IOP) levels and retinal ganglion cell (RGC) loss across different fixed-duration episodes of acute ocular hypertension (AOH). | - |
dcterms.abstract | Methods: AOH was induced in Thy1-YFP-H transgenic mice by inserting a needle connected to a saline solution container into the anterior chamber. Thirty-one groups were tested, each comprising three to five mice exposed to IOP levels ranging from 50 to 110 mm Hg in 5/10 mm Hg increments for 60/90/120 minutes and a sham control group. The YFP-expressing RGCs were quantified by confocal scanning laser ophthalmoscopy, whereas peripapillary ganglion cell complex thickness was measured using spectral-domain optical coherence tomography. Changes in RGC count and GCCT were determined from values measured 30 days after AOH relative to baseline (before AOH). | - |
dcterms.abstract | Results: In the 60-minute AOH groups, RGC loss varied even when IOP was increased up to 110 mm Hg (36.8%–68.2%). However, for longer durations (90 and 120 minutes), a narrow range of IOP levels (60–70 mm Hg for 90-minute duration; 55–65 mm Hg for 120-minute duration) produced a significant difference in RGC loss, ranging from <25% to >90%. Additionally, loss of YFP-expressing RGCs was comparable to that of total RGCs in the same retinas. | - |
dcterms.abstract | Conclusions: Reproducible RGC loss during AOH depends on precise durations and IOP thresholds. In the current study, the optimal choice is an AOH protocol set at 70 mm Hg for a duration of 90 minutes. | - |
dcterms.abstract | Translational Relevance: This study can assist in determining the optimal duration and intensity of IOP for the effective utilization of AOH models. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Translational vision science & technology, Mar. 2024, v. 13, no. 3, 17 | en_US |
dcterms.isPartOf | Translational vision science & technology | en_US |
dcterms.issued | 2024-03 | - |
dc.identifier.scopus | 2-s2.0-85188744095 | - |
dc.identifier.pmid | 38506800 | - |
dc.identifier.eissn | 2164-2591 | en_US |
dc.identifier.artn | 17 | en_US |
dc.description.validate | 202406 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a2877a | - |
dc.identifier.SubFormID | 48623 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Global STEM Professorship Scheme; Fundamental Research Funds of the State Key Laboratory of Ophthalmology; National Natural Science Foundation of China | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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i2164-2591-13-3-17_1710932907.77993.pdf | 2.1 MB | Adobe PDF | View/Open |
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