Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107443
DC Field | Value | Language |
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dc.contributor | School of Optometry | - |
dc.creator | Zhang, X | en_US |
dc.creator | Liang, Y | en_US |
dc.creator | Huang, Y | en_US |
dc.creator | Liu, S | en_US |
dc.creator | Li, Q | en_US |
dc.creator | Wang, S | en_US |
dc.creator | Wu, G | en_US |
dc.creator | Du, Z | en_US |
dc.creator | Wang, Y | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Hu, Y | en_US |
dc.creator | Zang, S | en_US |
dc.creator | Hu, Y | en_US |
dc.creator | Shang, X | en_US |
dc.creator | Zhang, X | en_US |
dc.creator | Zhang, L | en_US |
dc.creator | Brown, A | en_US |
dc.creator | Zhu, Z | en_US |
dc.creator | He, M | en_US |
dc.creator | Yu, H | en_US |
dc.date.accessioned | 2024-06-24T07:02:46Z | - |
dc.date.available | 2024-06-24T07:02:46Z | - |
dc.identifier.issn | 0146-0404 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/107443 | - |
dc.language.iso | en | en_US |
dc.publisher | Association for Research in Vision and Ophthalmology | en_US |
dc.rights | Copyright 2024 The Authors | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0). | en_US |
dc.rights | The following publication Xiayin Zhang, Yingying Liang, Yu Huang, Shunming Liu, Qinyi Li, Shan Wang, Guanrong Wu, Zijing Du, Yaxin Wang, Jinghui Wang, Yunyan Hu, Siwen Zang, Yijun Hu, Xianwen Shang, Xueli Zhang, Lei Zhang, Andrew Brown, Zhuoting Zhu, Mingguang He, Honghua Yu; Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety. Invest. Ophthalmol. Vis. Sci. 2024;65(3):12 is available at https://doi.org/10.1167/iovs.65.3.12. | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Depression | en_US |
dc.subject | Genetic overlap | en_US |
dc.subject | Glaucoma | en_US |
dc.subject | Intraocular pressure | en_US |
dc.title | Evaluation of the observational associations and shared genetics between glaucoma with depression and anxiety | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 65 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.1167/iovs.65.3.12 | en_US |
dcterms.abstract | Purpose: Glaucoma, a leading cause of blindness worldwide, is suspected to exhibit a notable association with psychological disturbances. This study aimed to investigate epidemiological associations and explore shared genetic architecture between glaucoma and mental traits, including depression and anxiety. | - |
dcterms.abstract | Methods: Multivariable logistic regression and Cox proportional hazards regression models were employed to investigate longitudinal associations based on UK Biobank. A stepwise approach was used to explore the shared genetic architecture. First, linkage disequilibrium score regression inferred global genetic correlations. Second, MiXeR analysis quantified the number of shared causal variants. Third, specific shared loci were detected through conditional/conjunctional false discovery rate (condFDR/conjFDR) analysis and characterized for biological insights. Finally, two-sample Mendelian randomization (MR) was conducted to investigate bidirectional causal associations. | - |
dcterms.abstract | Results: Glaucoma was significantly associated with elevated risks of hospitalized depression (hazard ratio [HR] = 1.54; 95% confidence interval [CI], 1.01–2.34) and anxiety (HR = 2.61; 95% CI, 1.70–4.01) compared to healthy controls. Despite the absence of global genetic correlations, MiXeR analysis revealed 300 variants shared between glaucoma and depression, and 500 variants shared between glaucoma and anxiety. Subsequent condFDR/conjFDR analysis discovered 906 single-nucleotide polymorphisms (SNPs) jointly associated with glaucoma and depression and two associated with glaucoma and anxiety. The MR analysis did not support robust causal associations but indicated the existence of pleiotropic genetic variants influencing both glaucoma and depression. | - |
dcterms.abstract | Conclusions: Our study enhances the existing epidemiological evidence and underscores the polygenic overlap between glaucoma and mental traits. This observation suggests a correlation shaped by pleiotropic genetic variants rather than being indicative of direct causal relationships. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Investigative ophthalmology and visual science, Mar. 2024, v. 65, no. 3, 12 | en_US |
dcterms.isPartOf | Investigative ophthalmology and visual science | en_US |
dcterms.issued | 2024-03 | - |
dc.identifier.scopus | 2-s2.0-85187451517 | - |
dc.identifier.eissn | 1552-5783 | en_US |
dc.identifier.artn | 12 | en_US |
dc.description.validate | 202406 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a2869 | - |
dc.identifier.SubFormID | 48595 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; China Postdoctoral Science Foundation; Personalized Medical Incubator Project; Precison Medicine Research and Industry Development in SIMQ; Guangdong Provincial People's Hospital for NSFC; Medical Scientific Research Foundation of Guangdong ProvinceScience and Technology Program of Guangzhou; Outstanding Young Talent Trainee Program of Guangdong Provincial People's Hospital | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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i1552-5783-65-3-12_1710149178.04859.pdf | 1.31 MB | Adobe PDF | View/Open |
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