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http://hdl.handle.net/10397/107387
Title: | COVID-19 and cognitive performance : a Mendelian randomization study | Authors: | Tang, CM Li, GHY Cheung, CL |
Issue Date: | 2023 | Source: | Frontiers in public health, 2023, v. 11, 1185957 | Abstract: | Background: A substantial proportion of individuals with COVID-19 experienced cognitive impairment after resolution of SARS-CoV-2 infection. We aimed to evaluate whether genetic liability to SARS-CoV-2 infection per se, or more severe COVID-19, is causally linked to cognitive deficit. Methods: We firstly performed univariable Mendelian randomization (MR) analysis to examine whether genetic liability to SARS-CoV-2 infection, hospitalized and severe COVID-19 is causally associated with cognitive performance. To dissect the causal pathway, multivariable MR (MVMR) analysis was conducted by adjusting for five inflammatory markers [C-reactive protein, interleukin (IL)-1β, IL-6, IL-8, and tumour necrosis factor α, as proxies of systemic inflammation]. Results: In univariable MR analysis, host genetic liability to SARS-CoV-2 infection was associated with lower cognitive performance [inverse variance weighted (IVW) analysis, estimate: −0.023; 95% Confidence Interval (CI): −0.038 to −0.009]. Such causal association was attenuated in MVMR analysis when we adjusted for the five correlated inflammatory markers in one analysis (IVW analysis, estimate: −0.022; 95% CI: −0.049 to 0.004). There was insufficient evidence of association for genetic liability to hospitalized and severe COVID-19 with cognitive performance. Conclusion: The causal effect of host genetic liability to SARS-CoV-2 infection on reduced cognitive performance may be mediated by systemic inflammation. Future studies examining whether anti-inflammatory agents could alleviate cognitive impairment in SARS-CoV-2-infected individuals are warranted. |
Keywords: | Cognitive performance COVID-19 Inflammatory markers Mendelian randomization SARS-CoV-2 infection |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in public health | EISSN: | 2296-2565 | DOI: | 10.3389/fpubh.2023.1185957 | Rights: | © 2023 Tang, Li and Cheung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Tang C-M, Li GH-Y and Cheung C-L (2023) COVID-19 and cognitive performance: a Mendelian randomization study. Front. Public Health 11:1185957 is available at https://doi.org/10.3389/fpubh.2023.1185957. |
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