Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/107321
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dc.contributorDepartment of Health Technology and Informaticsen_US
dc.creatorChiyanika, Cen_US
dc.creatorHui, SCNen_US
dc.creatorSin, DMCen_US
dc.creatorShumbayawonda, Een_US
dc.creatorWong, SKHen_US
dc.creatorNg, EKWen_US
dc.creatorYip, TCFen_US
dc.creatorWong, VWSen_US
dc.creatorChu, WCWen_US
dc.date.accessioned2024-06-14T06:36:53Z-
dc.date.available2024-06-14T06:36:53Z-
dc.identifier.issn2223-4292en_US
dc.identifier.urihttp://hdl.handle.net/10397/107321-
dc.language.isoenen_US
dc.publisherAME Publishing Companyen_US
dc.rights© Quantitative Imaging in Medicine and Surgery. All rights reserved.en_US
dc.rightsOpen Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.en_US
dc.rightsThe following publication Chiyanika C, Hui SCN, Sin DMC, Shumbayawonda E, Wong SKH, Ng EKW, Yip TCF, Wong VWS, Chu WCW. The effectiveness of magnetic resonance imaging (MRI) iron corrected T1 in monitoring metabolic dysfunction-associated steatohepatitis in obesity following bariatric surgery and lifestyle modification: a prospective cohort study. Quant Imaging Med Surg 2024;14(7):4659-4674 is available at https://doi.org/10.21037/qims-24-148.en_US
dc.subjectIron corrected T1 (cT1)en_US
dc.subjectMagnetic resonance imaging biomarkers (MRI biomarkers)en_US
dc.subjectMetabolic dysfunction-associated steatohepatitis (MASH)en_US
dc.subjectMetabolic dysfunction-associated steatotic liver disease (MASLD)en_US
dc.subjectProton density fat fraction (PDFF)en_US
dc.titleThe effectiveness of magnetic resonance imaging (MRI) iron corrected T1 in monitoring metabolic dysfunction-associated steatohepatitis in obesity following bariatric surgery and lifestyle modification : a prospective cohort studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage4659en_US
dc.identifier.epage4674en_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.doi10.21037/qims-24-148en_US
dcterms.abstractBackground: Bariatric surgery and lifestyle modification are important treatments for obesity, a risk factor for metabolic dysfunction-associated steatohepatitis (MASH). Studies have related weight reduction with changes in MASH, however, few have used imaging to investigate effects on liver health. We evaluated differences in liver response to obesity treatment using disease activity iron corrected T1 (cT1) and proton density fat fraction (PDFF) in patients with both obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).en_US
dcterms.abstractMethods: Thirty-four patients with obesity and MASLD were recruited between March 2019 to February 2022 from a tertiary hospital in this longitudinal study; 13 underwent laparoscopic sleeve gastrectomy (LSG) alongside intraoperative liver biopsy, and 21 underwent a 4-month lifestyle modification program (LMP). All patients had multi-parametric magnetic resonance imaging (MRI) at baseline and 4-months. Diagnostic accuracy to identify MASH was assessed using the area under receiver operating characteristic (AUROC) curve.en_US
dcterms.abstractResults: Four (31%) of patients in the LSG group had MASH [non-alcoholic steatohepatitis (NAS) activity score ≥4] on liver biopsy. PDFF and cT1 correlated with the NAS activity score [r=0.81, 95% confidence interval (CI): 0.453 to 0.943, P<0.001] and (r=0.70, 95% CI: 0.228 to 0.907, P=0.008, respectively). There was good AUROC curve for cT1 (0.89, 95% CI: 0.67 to 1.00, P=0.031) and PDFF (0.83, 95% CI: 0.57 to 1.00, P=0.064) to identify MASH. At follow-up, weight reduction −22.8% (P=0.013) vs. −1.3% (P=0.262) resulted in cT1 reduction of −8.04% (864 ms, P=0.025) vs. −3.87% (907 ms, P=0.083) in the LSG vs. LMP group, respectively. Significant differences between interventions were observed for percentage PDFF decrease (−64.52% vs. −29.16%, P=0.001). Both biomarkers were significantly reduced in the LSG group (cT1 by −8.04%, P=0.025, PDFF by −64.52%, P=0.012), while only PDFF (−29.16%, P=0.012) was significantly reduced in the LMP group.en_US
dcterms.abstractConclusions: MRI biomarkers may have some utility to monitor MASH following intervention in patients with obesity allowing objective comparison between intervention strategies. Compared to LMP, LSG was more effective in improving liver health.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationQuantitative imaging in medicine and surgery, 1 July 2024, v. 14, no. 7, p. 4659-4674en_US
dcterms.isPartOfQuantitative imaging in medicine and surgeryen_US
dcterms.issued2024-07-01-
dc.identifier.eissn2223-4306en_US
dc.description.validate202406 bcchen_US
dc.description.oaVersion of Recorden_US
dc.identifier.FolderNumbera2817-
dc.identifier.SubFormID48459-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextThe Chinese University of Hong Kong Direct Grant for Researchen_US
dc.description.pubStatusPublisheden_US
dc.description.oaCategoryCCen_US
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