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http://hdl.handle.net/10397/107307
Title: | Metal-drug coordination nanoparticles and hydrogels for enhanced delivery | Authors: | Wong, KY Nie, Z Wong, MS Wang, Y Liu, J |
Issue Date: | 2024 | Source: | Advanced materials, First published: 11 April 2024, Early View, https://doi.org/10.1002/adma.202404053 | Abstract: | Drug delivery is a key component of nanomedicine, and conventional delivery relies on the adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles contain metal ions, such as metal–organic frameworks, metal oxides, transition metal dichalcogenides, MXene, and noble metal nanoparticles. These materials have a high metal content and pose potential long-term toxicity concerns leading to difficulties for clinical approval. In this review, recent developments are summarized in the use of drug molecules as ligands for metal coordination forming various nanomaterials and soft materials. In these cases, the drug-to-metal ratio is much higher than conventional adsorption-based strategies. The drug molecules are divided into small-molecule drugs, nucleic acids, and proteins. The formed hybrid materials mainly include nanoparticles and hydrogels, upon which targeting ligands can be grafted to improve efficacy and further decrease toxicity. The application of these materials for addressing cancer, viral infection, bacterial infection inflammatory bowel disease, and bone diseases is reviewed. In the end, some future directions are discussed from fundamental research, materials science, and medicine. | Keywords: | DNA Drug delivery Hydrogels Metal coordination Nanomedicine |
Publisher: | Wiley-VCH Verlag GmbH & Co. KGaA | Journal: | Advanced materials | ISSN: | 0935-9648 | EISSN: | 1521-4095 | DOI: | 10.1002/adma.202404053 | Rights: | © 2024 The Authors. Advanced Materials published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original workis properly cited and is not used for commercial purposes. The following publication K.-Y. Wong, Z. Nie, M.-S. Wong, Y. Wang, J. Liu, Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery. Adv. Mater. 2024, 2404053 is available at https://doi.org/10.1002/adma.202404053. |
Appears in Collections: | Journal/Magazine Article |
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Wong_Metal-Drug_Coordination_Nanoparticles.pdf | 11.23 MB | Adobe PDF | View/Open |
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