Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/107055
DC Field | Value | Language |
---|---|---|
dc.contributor | School of Optometry | en_US |
dc.creator | Zhang, S | en_US |
dc.creator | Chen, Y | en_US |
dc.creator | Li, Z | en_US |
dc.creator | Wang, W | en_US |
dc.creator | Xuan, M | en_US |
dc.creator | Zhang, J | en_US |
dc.creator | Hu, Y | en_US |
dc.creator | Chen, Y | en_US |
dc.creator | Xiao, O | en_US |
dc.creator | Yin, Q | en_US |
dc.creator | Zheng, Y | en_US |
dc.creator | He, M | en_US |
dc.creator | Han, X | en_US |
dc.date.accessioned | 2024-06-12T03:46:02Z | - |
dc.date.available | 2024-06-12T03:46:02Z | - |
dc.identifier.issn | 2168-6165 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/107055 | - |
dc.language.iso | en | en_US |
dc.publisher | American Medical Association | en_US |
dc.rights | ©2023 American Medical Association. All rights reserved. | en_US |
dc.rights | The following publication Zhang S, Chen Y, Li Z, et al. Axial Elongation Trajectories in Chinese Children and Adults With High Myopia. JAMA Ophthalmol. 2024;142(2):87–94 is available at https://doi.org/10.1001/jamaophthalmol.2023.5835. | en_US |
dc.title | Axial elongation trajectories in Chinese children and adults with high myopia | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 87 | en_US |
dc.identifier.epage | 94 | en_US |
dc.identifier.volume | 142 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.1001/jamaophthalmol.2023.5835 | en_US |
dcterms.abstract | Importance: Understanding the long-term axial elongation trajectory in high myopia is important to prevent blindness. | en_US |
dcterms.abstract | Objective: To evaluate axial elongation trajectories and related visual outcomes in children and adults with high myopia. | en_US |
dcterms.abstract | Design, Setting, and Participants: In this cohort study, participants in the Zhongshan Ophthalmic Centre–Brien Holden Vision Institute high myopia cohort were followed up every other year for 8 years. Participants with axial length measurements at baseline (2011 or 2012) and at least 1 follow-up visit were included. Participants were grouped according to baseline age as children and adolescents (7 to <18 years), young adults (18 to <40 years), and older adults (≥40 to 70 years). Data were analyzed from November 1, 2022, to June 1, 2023. | en_US |
dcterms.abstract | Exposure: High myopia (spherical power ≤−6.00 diopters). | en_US |
dcterms.abstract | Main Outcomes and Measures: Longitudinal axial elongation trajectories were identified by cluster analysis. Axial elongation rates were calculated by linear mixed-effects models. A 2-sided P < .05 was defined as statistically significant. | en_US |
dcterms.abstract | Results: A total of 793 participants (median [range] age, 17.8 [6.8-69.7] years; 418 females [52.7%]) and 1586 eyes were included in the analyses. Mean axial elongation rates were 0.46 mm/y (95% CI, 0.44-0.48 mm/y) for children and adolescents, 0.07 mm/y (95% CI, 0.06-0.09 mm/y) for young adults, and 0.13 mm/y (95% CI, 0.07-0.19 mm/y) for older adults. Cluster analysis identified 3 axial elongation trajectories, with the stable, moderate, and rapid progression trajectories having mean axial elongation rates of 0.02 mm/y (95% CI, 0.01-0.02 mm/y), 0.12 mm/y (95% CI, 0.11-0.13 mm/y), and 0.38 mm/y (95% CI, 0.35-0.42 mm/y), respectively. At 8 years of follow-up, compared with the stable progression trajectory, the rapid progression trajectory was associated with a 6.92 times higher risk of developing pathological myopic macular degeneration (defined as diffuse or patchy chorioretinal atrophy or macular atrophy; odds ratio, 6.92 [95% CI, 1.07-44.60]; P = .04), and it was associated with a 0.032 logMAR decrease in best-corrected visual acuity (β = 0.032 [95% CI, 0.001-0.063]; P = .04). | en_US |
dcterms.abstract | Conclusions and Relevance: The findings of this 8-year follow-up study suggest that axial length in high myopia continues to increase from childhood to late adulthood following 3 distinct trajectories. At 8 years of follow-up, the rapid progression trajectory was associated with a higher risk of developing pathological myopic macular degeneration and poorer best-corrected visual acuity compared with the stable progression trajectory. These distinct axial elongation trajectories could prove valuable for early identification and intervention for high-risk individuals. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | JAMA ophthalmology, Feb. 2024, v. 142, no. 2, p. 87-94 | en_US |
dcterms.isPartOf | JAMA ophthalmology | en_US |
dcterms.issued | 2024-02 | - |
dc.identifier.scopus | 2-s2.0-85181490433 | - |
dc.identifier.pmid | 38153745 | - |
dc.identifier.eissn | 2168-6173 | en_US |
dc.description.validate | 202406 bcwh | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a2774 | - |
dc.identifier.SubFormID | 48302 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
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Zhang_Axial_Elongation_Trajectories.pdf | 430.76 kB | Adobe PDF | View/Open |
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