Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106203
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Social Sciences | en_US |
dc.creator | Tang, PCT | en_US |
dc.creator | Chan, MKK | en_US |
dc.creator | Chung, JYF | en_US |
dc.creator | Chan, ASW | en_US |
dc.creator | Zhang, DM | en_US |
dc.creator | Li, CJ | en_US |
dc.creator | Leung, KT | en_US |
dc.creator | Ng, CSH | en_US |
dc.creator | Wu, Y | en_US |
dc.creator | To, KF | en_US |
dc.creator | Lan, HY | en_US |
dc.creator | Tang, PMK | en_US |
dc.date.accessioned | 2024-05-03T00:45:45Z | - |
dc.date.available | 2024-05-03T00:45:45Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/106203 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication P. C.-T. Tang, M. K.-K. Chan, J. Y.-F. Chung, A. S.-W. Chan, D. Zhang, C. Li, K.-T. Leung, C. S.-H. Ng, Y. Wu, K.-F. To, H.-Y. Lan, P. M.-K. Tang, Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non-Small-Cell Lung Carcinoma. Adv. Sci. 2024, 11, 2302203 is available at https://dx.doi.org/10.1002/advs.202302203. | en_US |
dc.subject | Cancer-associated fibroblasts(CAF) | en_US |
dc.subject | Macrophage-myofibroblast transition (MMT) | en_US |
dc.subject | Runx1 | en_US |
dc.subject | Smad3 | en_US |
dc.subject | Tumor-associated macrophages (TAM) | en_US |
dc.title | Hematopoietic transcription factor RUNX1 is essential for promoting macrophage-myofibroblast transition in non-small-cell lung carcinoma | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.doi | 10.1002/advs.202302203 | en_US |
dcterms.abstract | Macrophage-myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro-tumoral cancer-associated fibroblasts (CAFs) in non-small cell lung carcinoma (NSCLC) in a TGF-beta 1/Smad3 dependent manner. Better understanding its regulatory signaling in tumor microenvironment (TME) may identify druggable target for the development of precision medicine. Here, by dissecting the transcriptome dynamics of tumor-associated macrophage at single-cell resolution, a crucial role of a hematopoietic transcription factor Runx1 in MMT formation is revealed. Surprisingly, integrative bioinformatic analysis uncovers Runx1 as a key regulator in the downstream of MMT-specific TGF-beta 1/Smad3 signaling. Stromal Runx1 level positively correlates with the MMT-derived CAF abundance and mortality in NSCLC patients. Mechanistically, macrophage-specific Runx1 promotes the transcription of genes related to CAF signatures in MMT cells at genomic level. Importantly, macrophage-specific genetic deletion and systemic pharmacological inhibition of TGF-beta 1/Smad3/Runx1 signaling effectively prevent MMT-driven CAF and tumor formation in vitro and in vivo, representing a potential therapeutic target for clinical NSCLC. Macrophage-myofibroblast transition (MMT) is an important source of cancer-associated fibroblasts (CAFs) in non-small cell lung carcinoma (NSCLC). Here, the hematopoietic transcription factor Runx1 is discovered as a key regulator of MMT in cancer patients. Macrophage-specific and systemic inhibition of Runx1 effectively blocks MMT-driven tumor formation in vivo, representing a druggable therapeutic target to eliminate tumor-promoting CAFs in NSCLC patients. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 5 Jan. 2024, v. 11, no. 1, 2302203 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2024-01-05 | - |
dc.identifier.isi | WOS:001101898200001 | - |
dc.identifier.artn | 2302203 | en_US |
dc.description.validate | 202405 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Health and Medical Research Fund | en_US |
dc.description.fundingText | Health and Medical Research Fund | en_US |
dc.description.fundingText | CU Medicine Passion for Perfection Scheme | en_US |
dc.description.fundingText | Faculty Innovation Award | en_US |
dc.description.fundingText | CUHK Strategic Seed Funding for Collaborative Research Scheme | en_US |
dc.description.fundingText | Direct Grant for Research | en_US |
dc.description.fundingText | Postdoctoral Fellowship Scheme | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tang_Hematopoietic_Transcription_RUNX1.pdf | 27.15 MB | Adobe PDF | View/Open |
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