Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106090
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Tsang, HF | en_US |
dc.creator | Yu, ACS | en_US |
dc.creator | Yim, AKY | en_US |
dc.creator | Jin, NA | en_US |
dc.creator | Wu, YO | en_US |
dc.creator | Cheng, HYL | en_US |
dc.creator | Cheung, WL | en_US |
dc.creator | Leung, WMS | en_US |
dc.creator | Lam, KW | en_US |
dc.creator | Hung, TN | en_US |
dc.creator | Chan, LS | en_US |
dc.creator | Chiou, J | en_US |
dc.creator | Pei, XM | en_US |
dc.creator | Lee, OYA | en_US |
dc.creator | Cho, WCS | en_US |
dc.creator | Wong, SCC | en_US |
dc.date.accessioned | 2024-05-03T00:45:08Z | - |
dc.date.available | 2024-05-03T00:45:08Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/106090 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2023 Tsang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication Tsang HF, Yu ACS, Yim AKY, Jin N, Wu YO, Cheng HYL, et al. (2023) The clinical characteristics of pediatric patients infected by SARS-CoV-2 Omicron variant and whole viral genome sequencing analysis. PLoS ONE 18(3): e0282389 is available at https://dx.doi.org/10.1371/journal.pone.0282389. | en_US |
dc.title | The clinical characteristics of pediatric patients infected by SARS-CoV-2 Omicron variant and whole viral genome sequencing analysis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0282389 | en_US |
dcterms.abstract | Pediatric population was generally less affected clinically by SARS-CoV-2 infection. Few pediatric cases of COVID-19 have been reported compared to those reported in infected adults. However, a rapid increase in the hospitalization rate of SARS-CoV-2 infected pediatric patients was observed during Omicron variant dominated COVID-19 outbreak. In this study, we analyzed the B.1.1.529 (Omicron) genome sequences collected from pediatric patients by whole viral genome amplicon sequencing using Illumina next generation sequencing platform, followed by phylogenetic analysis. The demographic, epidemiologic and clinical data of these pediatric patients are also reported in this study. Fever, cough, running nose, sore throat and vomiting were the more commonly reported symptoms in children infected by Omicron variant. A novel frameshift mutation was found in the ORF1b region (NSP12) of the genome of Omicron variant. Seven mutations were identified in the target regions of the WHO listed SARS-CoV-2 primers and probes. On protein level, eighty-three amino acid substitutions and fifteen amino acid deletions were identified. Our results indicate that asymptomatic infection and transmission among children infected by Omicron subvariants BA.2.2 and BA.2.10.1 are not common. Omicron may have different pathogenesis in pediatric population. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2023, v. 18, no. 3, e0282389 | en_US |
dcterms.isPartOf | PLoS one | en_US |
dcterms.issued | 2023 | - |
dc.identifier.isi | WOS:001149361800008 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.artn | e0282389 | en_US |
dc.description.validate | 202405 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Hong Kong Innovation and Technology Fund University-Industry Collaborative Programme; Lim Peng Suan Charitable Trust Research Grant | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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journal.pone.0282389.pdf | 1.23 MB | Adobe PDF | View/Open |
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