Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/106056
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Wu, Y | en_US |
dc.creator | Chau, HF | en_US |
dc.creator | Yeung, YH | en_US |
dc.creator | Thor, W | en_US |
dc.creator | Kai, HY | en_US |
dc.creator | Chan, WL | en_US |
dc.creator | Wong, KL | en_US |
dc.date.accessioned | 2024-05-02T08:30:49Z | - |
dc.date.available | 2024-05-02T08:30:49Z | - |
dc.identifier.issn | 1433-7851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/106056 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distributionin any med-ium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights | The following publication YWu, Y., Chau, H. F., Yeung, Y. H., Thor, W., Kai, H. Y., Chan, W. L., & Wong, K. L. (2022). Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin. Angewandte Chemie International Edition, 61(34), e202207532 is available at https://doi.org/10.1002/anie.202207532. | en_US |
dc.subject | Fluorescent peptides | en_US |
dc.subject | Multivalent porphyrin–peptide conjugates | en_US |
dc.subject | Porphyrins | en_US |
dc.subject | Solid-phase peptide synthesis | en_US |
dc.subject | Targeted bioimaging | en_US |
dc.title | Versatile synthesis of multivalent porphyrin–peptide conjugates by direct porphyrin construction on resin | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 34 | en_US |
dc.identifier.doi | 10.1002/anie.202207532 | en_US |
dcterms.abstract | Multifunctional porphyrin–peptide conjugates with different propensities for self-assembly into various supramolecular nanoarchitectures play important roles in advanced materials and biomedical research. However, preparing prefunctionalized core porphyrins by traditional low-yielding statistical synthesis and purifying them after peptide ligation through many rounds of HPLC purification is tedious and unsustainable. Herein, we report a novel integrated solid-phase synthetic protocol for the construction of porphyrin moieties from simple aldehydes and dipyrromethanes on resin-bound peptides directly to form mono-, cis/trans-di-, and trivalent porphyrin–peptide conjugates in a highly efficient and controllable manner; moreover, only single final-stage HPLC purification of the products is needed. This efficient strategy enables the rapid, greener, and substrate-controlled diversity-oriented synthesis of multivalent porphyrin–(long) peptide conjugate libraries for multifarious biological and materials applications. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Angewandte chemie international edition, 22 Aug. 2022, v. 61, no. 34, e202207532 | en_US |
dcterms.isPartOf | Angewandte chemie international edition | en_US |
dcterms.issued | 2022-08-22 | - |
dc.identifier.scopus | 2-s2.0-85133659576 | - |
dc.identifier.pmid | 35730925 | - |
dc.identifier.eissn | 1521-3773 | en_US |
dc.identifier.artn | e202207532 | en_US |
dc.description.validate | 202404 bcwh | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Others | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Dr Mok Man Hung Endowed Professorship in Chemistry, HKBU‐Durham Lanthanide Joint Research Center—Lanthanide Tools for Systems Medicine; the Centre for Medical Engineering of Molecular and Biological Probes; the Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Wu_Versatile_Synthesis_Multivalent.pdf | 10.43 MB | Adobe PDF | View/Open |
Page views
9
Citations as of Jun 30, 2024
Downloads
1
Citations as of Jun 30, 2024
SCOPUSTM
Citations
13
Citations as of Jul 4, 2024
WEB OF SCIENCETM
Citations
9
Citations as of Jul 4, 2024
![](/image/google_scholar.jpg)
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.