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http://hdl.handle.net/10397/105907
Title: | Roles and mechanisms of astragaloside IV in combating neuronal aging | Authors: | Zaman, Q Zhang, D Reddy, OS Wong, WT Lai, WF |
Issue Date: | 16-Nov-2022 | Source: | Aging and disease, 16 Nov. 2022, v. 13, no. 6, p. 1845-1861 | Abstract: | Aging can lead to changes in the cellular milieu of the brain. These changes may exacerbate, resulting in pathological phenomena (including impaired bioenergetics, aberrant neurotransmission, compromised resilience and neuroplasticity, mitochondrial dysfunction, and the generation of free radicals) and the onset of neurodegenerative diseases. Furthermore, alterations in the energy-sensing pathways can accelerate neuronal aging but the exact mechanism of neural aging is still elusive. In recent decades, the use of plant-derived compounds, including astragaloside IV, to treat neuronal aging and its associated diseases has been extensively investigated. This article presents the current understanding of the roles and mechanisms of astragaloside IV in combating neuronal aging. The ability of the agent to suppress oxidative stress, to attenuate inflammatory responses and to maintain mitochondrial integrity will be discussed. Important challenges to be tacked for further development of astragaloside IV-based pharmacophores will be highlighted for future research. | Keywords: | Astragaloside IV Energy-sensing pathways Mitochondrial dysfunction Neurodegeneration Neuronal aging |
Publisher: | Buck Institute for Age Research | Journal: | Aging and disease | EISSN: | 2152-5250 | DOI: | 10.14336/AD.2022.0126 | Rights: | Copyright: © 2022 Zaman Q et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The following publication Qumar Zaman , Dahong Zhang , Obireddy Sreekanth Reddy , Wing-Tak Wong , Wing-Fu Lai. Roles and Mechanisms of Astragaloside IV in Combating Neuronal Aging. Aging and disease. 2022, 13(6): 1845-1861 is available at https://doi.org/10.14336/AD.2022.0126. |
Appears in Collections: | Journal/Magazine Article |
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Zaman_Roles_Mechanisms_Astragaloside.pdf | 1.08 MB | Adobe PDF | View/Open |
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