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http://hdl.handle.net/10397/105872
DC Field | Value | Language |
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dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Wu, Y | - |
dc.creator | Liu, Q | - |
dc.creator | Wang, Y | - |
dc.creator | Li, F | - |
dc.creator | Chan, LWC | - |
dc.creator | Wen, Y | - |
dc.creator | Yang, F | - |
dc.creator | Xiang, Y | - |
dc.creator | Duan, Q | - |
dc.creator | Luo, P | - |
dc.creator | Lei, P | - |
dc.date.accessioned | 2024-04-23T04:31:56Z | - |
dc.date.available | 2024-04-23T04:31:56Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105872 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.rights | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_US |
dc.rights | The following publication Wu, Y., Liu, Q., Wang, Y. et al. Diagnostic efficiency on ultrasound shear wave elastography in evaluation of steatosis severity for non-alcoholic fatty liver disease: a rat model. Eur J Med Res 28, 75 (2023) is available at https://doi.org/10.1186/s40001-023-01042-5. | en_US |
dc.subject | Fat quantification | en_US |
dc.subject | Hepatic steatosis | en_US |
dc.subject | Methionine choline deficiency | en_US |
dc.subject | Non-alcoholic fatty liver disease | en_US |
dc.subject | Shear wave elastography | en_US |
dc.title | Diagnostic efficiency on ultrasound shear wave elastography in evaluation of steatosis severity for non-alcoholic fatty liver disease : a rat model | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 28 | - |
dc.identifier.doi | 10.1186/s40001-023-01042-5 | - |
dcterms.abstract | Background: The pathological feature of steatosis affects the elasticity values measured by shear wave elastography (SWE) is still controversial in non-alcoholic fatty liver disease (NAFLD). The aim of this study is to demonstrate the influence of steatosis on liver stiffness measured by SWE on a rat model with NAFLD and analyze feasibility of SWE for grading steatosis in absence of fibrosis. | - |
dcterms.abstract | Methods: Sixty-six rats were fed with methionine choline deficient diet or standard diet to produce various stages of steatosis; 48 rats were available for final analysis. Rats underwent abdominal ultrasound SWE examination and pathological assessment. Liver histopathology was analyzed to assess the degree of steatosis, inflammation, ballooning, and fibrosis according to the non-alcoholic fatty liver disease activity score. The diagnostic performance of SWE for differentiating steatosis stages was estimated according to the receiver operating characteristic (ROC) curve. Decision curve analysis (DCA) was conducted to determine clinical usefulness and the areas under DCA (AUDCAs) calculated. | - |
dcterms.abstract | Results: In multivariate analysis, steatosis was an independent factor affecting the mean elastic modules (B = 1.558, P < 0.001), but not inflammation (B = − 0.031, P = 0.920) and ballooning (B = 0.216, P = 0.458). After adjusting for inflammation and ballooning, the AUROC of the mean elasticity for identifying S ≥ S1 was 0.956 (95%CI: 0.872–0.998) and the AUDCA, 0.621. The AUROC for distinguishing S ≥ S2 and S = S3 was 0.987 (95%CI: 0.951–1.000) and 0.920 (95%CI: 0.816–0.986) and the AUDCA was 0.506 and 0.256, respectively. | - |
dcterms.abstract | Conclusions: Steatosis is associated with liver stiffness and SWE may have the feasibility to be introduced as an assistive technology in grading steatosis for patients with NAFLD in absence of fibrosis. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | European journal of medical research, 2023, v. 28, 75 | - |
dcterms.isPartOf | European journal of medical research | - |
dcterms.issued | 2023 | - |
dc.identifier.scopus | 2-s2.0-85147835005 | - |
dc.identifier.pmid | 36774529 | - |
dc.identifier.eissn | 2047-783X | - |
dc.identifier.artn | 75 | - |
dc.description.validate | 202404 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Natural Science Foundation of China; Science and Technology Projects of Guizhou Province; Hong Kong Scholar Program | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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s40001-023-01042-5.pdf | 2.16 MB | Adobe PDF | View/Open |
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