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http://hdl.handle.net/10397/105861
DC Field | Value | Language |
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dc.contributor | School of Nursing | - |
dc.creator | Chan, CW | - |
dc.creator | Molassiotis, A | - |
dc.creator | Lee, HKK | - |
dc.date.accessioned | 2024-04-23T04:31:52Z | - |
dc.date.available | 2024-04-23T04:31:52Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105861 | - |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central Ltd. | en_US |
dc.rights | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_US |
dc.rights | The following publication Chan, C.W., Molassiotis, A. & Lee, H.K.K. Clinical and microbiological profiles in post-chemotherapy neutropenic fever in hematological malignancy: exploration of clinical phenotype patterns by two-step cluster analysis. BMC Infect Dis 23, 226 (2023) is available at https://doi.org/10.1186/s12879-023-08218-8. | en_US |
dc.subject | Clinical and microbiological profiles | en_US |
dc.subject | Febrile neutropenia | en_US |
dc.subject | Hematological malignancy | en_US |
dc.subject | Phenotype pattern | en_US |
dc.subject | Post-chemotherapy neutropenic fever | en_US |
dc.subject | Two-step cluster analysis | en_US |
dc.title | Clinical and microbiological profiles in post-chemotherapy neutropenic fever in hematological malignancy : exploration of clinical phenotype patterns by two-step cluster analysis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 23 | - |
dc.identifier.doi | 10.1186/s12879-023-08218-8 | - |
dcterms.abstract | Background: Epidemiology of infectious diseases causing febrile illness varies geographically with human attributes. Periodic institutional surveillance of clinical and microbiological profiles in adding data to updating trends, modulating pharmatherapeutics, signifying possible excessive treatments and risk of drug resistance in post-chemotherapy neutropenic fever (NF) in hematological malignancy (HM) is limited. We aimed to review institutional clinical and microbiological data and explore clinical phenotype pattern groups among data. | - |
dcterms.abstract | Methods: Available data from 372 NF episodes were included. Demographics, types of malignancies, laboratory data, antimicrobial treatments and febrile-related outcome data such as predominant pathogens and microbiological diagnosed infections (MDIs) were collected. Descriptive statistics, two-step cluster analysis and non-parametric tests were employed. | - |
dcterms.abstract | Results: The occurrences of microbiological diagnosed bacterial infections (MDBIs; 20.2%) and microbiological diagnosed fungal infections (MDFIs; 19.9%) were almost equal. Gram-negative pathogens (11.8%) were comparable with gram-positive pathogens (9.9%), with gram-negative being slightly predominant. Death rate was 7.5%. Two-step cluster analysis yielded four distinct clinical phenotype pattern (cluster) groups: cluster 1 ‘lymphomas without MDIs’, cluster 2 ‘acute leukemias MDBIs’, cluster 3 ‘acute leukemias MDFIs’ and cluster 4 ‘acute leukemias without MDIs’. Considerable NF events with antibiotic prophylaxis being not identified as MDI might have cases in low-risk with non-infectious reasons causing febrile reactions that might possibly not require prophylaxis. | - |
dcterms.abstract | Conclusions: Regular institutional surveillance with active parameter assessments to signify risk levels in the post-chemotherapy stage, even prior to the onset of fever, might be an evidence-based strategy in the management of NF in HM. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | BMC infectious diseases, 2023, v. 23, 226 | - |
dcterms.isPartOf | BMC infectious diseases | - |
dcterms.issued | 2023 | - |
dc.identifier.scopus | 2-s2.0-85152360936 | - |
dc.identifier.pmid | 37055745 | - |
dc.identifier.eissn | 1471-2334 | - |
dc.identifier.artn | 226 | - |
dc.description.validate | 202404 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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s12879-023-08218-8.pdf | 1 MB | Adobe PDF | View/Open |
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