Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105822
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Huang, Y | en_US |
dc.creator | Lum, JT | en_US |
dc.creator | Ho, WK | en_US |
dc.creator | Leung, KSY | en_US |
dc.date.accessioned | 2024-04-23T04:31:34Z | - |
dc.date.available | 2024-04-23T04:31:34Z | - |
dc.identifier.issn | 2051-8153 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/105822 | - |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | This journal is © The Royal Society of Chemistry 2023 | en_US |
dc.rights | This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/). | en_US |
dc.rights | The following publication Huang, Y., Lum, J. T.-S., Ho, W.-K., & Leung, K. S.-Y. (2023). Interactions between cerium dioxide nanoparticles and arsenite change their biological fate in the gastrointestinal tract of mice [10.1039/D3EN00109A]. Environmental Science: Nano, 10(6), 1585-1598 is available at https://doi.org/10.1039/D3EN00109A. | en_US |
dc.title | Interactions between cerium dioxide nanoparticles and arsenite change their biological fate in the gastrointestinal tract of mice | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1585 | en_US |
dc.identifier.epage | 1598 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.doi | 10.1039/d3en00109a | en_US |
dcterms.abstract | The large-scale production of engineered nanoparticles (ENPs), such as cerium dioxide nanoparticles (CeO2 NPs), raises concerns towards their impact on human health. The co-existence of ENPs and heavy metals in the natural environment is particularly worrisome because people are ingesting them. In this study, the behaviors of CeO2 NPs and arsenite (As(III)) during the digestive process were first investigated using an in vitro gastrointestinal tract (GIT) model, and then studied in a mouse model via oral co-exposure. The results suggest that CeO2 NPs of both 10 nm and 30 nm in diameter strongly adsorbed As(III) during the digestive process, resulting in the decreased bioaccessibility of As in the GIT fluids. Corresponding to the decreased As bioaccessibility obtained from the in vitro GIT model, exposure to a 10 nm CeO2 NP—As(III) mixture led to a decrease in As(III) bioaccumulation in organs. However, exposure to a 30 nm CeO2 NP—As(III) mixture increased the relative bioavailability of Ce and As in mice. Interestingly, toxicity enhancement was observed in the 30 nm CeO2 NP—As(III) mixture exposure group, probably due to the redox reaction between Ce(IV) and As(III) taking place on the NP surface, affecting the As(III) metabolism in the liver. Our findings showed the first step in elucidating the effect of two types of pollutants increasingly found in our environment, ENPs and heavy metals, on mammalian health. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Environmental science : NANO, 1 June 2023, v. 10, no. 6, p. 1585-1598 | en_US |
dcterms.isPartOf | Environmental science : NANO | en_US |
dcterms.issued | 2023-06-01 | - |
dc.identifier.scopus | 2-s2.0-85159206785 | - |
dc.identifier.eissn | 2051-8161 | en_US |
dc.description.validate | 202404 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | University Grants Committee | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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d3en00109a.pdf | 3.89 MB | Adobe PDF | View/Open |
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